Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.69 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | FBP1 | P09467 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7802850 | 0.86 | EGFR (0.66) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL7807527 | 0.85 | EGFR (0.74) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL27906527 | 0.85 | EGFR (0.81) | EGFRERBB2FBP1 | |
| SCHEMBL8312640 | 0.84 | EGFR (0.77) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL8870766 | 0.83 | EGFR (0.66) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL7811115 | 0.83 | EGFR (0.60) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL1418218 | 0.83 | EGFR (0.82) | EGFRERBB2MAPK1HIF1AFBP1 | |
| SCHEMBL7811745 | 0.83 | EGFR (0.64) | EGFRERBB2MAPK1HTTHIF1A | |
| Hydrochloric Acid SCHEMBL7809217 | 0.82 | EGFR (0.80) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL1766075 | 0.82 | EGFR (0.64) | EGFRERBB2FBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0635498-B1 | Quinazoline derivatives and their use as anti-cancer agents | SYNGENTA LTD (GB) | 2001-04-18 | — | — | EP | claimed |
| US-5475001-A | Quinazoline derivatives | ZENECA LIMITED (GB) | 1995-12-12 | — | — | US | claimed |
| WO-1995003283-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS ANTI-CANCER AGENTS | ZENECA LIMITED (GB) | 1995-02-02 | — | — | WO | claimed |
| EP-0635498-A1 | Quinazoline derivatives and their use as anti-cancer agents | ZENECA LIMITED (GB) | 1995-01-25 | — | — | EP | claimed |
| EP-0635498-B1 | Quinazoline derivatives and their use as anti-cancer agents | SYNGENTA LTD (GB) | 2001-04-18 | — | — | EP | disclosed |
| US-5475001-A | Quinazoline derivatives | ZENECA LIMITED (GB) | 1995-12-12 | — | — | US | disclosed |
| WO-1995003283-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS ANTI-CANCER AGENTS | ZENECA LIMITED (GB) | 1995-02-02 | — | — | WO | disclosed |
| EP-0635498-A1 | Quinazoline derivatives and their use as anti-cancer agents | ZENECA LIMITED (GB) | 1995-01-25 | — | — | EP | disclosed |