Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.64 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7809227 | 0.86 | EGFR (0.64) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL7809386 | 0.83 | EGFR (0.69) | EGFRERBB2MAPK1HTTHIF1A | |
| Hydrochloric Acid SCHEMBL7811143 | 0.83 | EGFR (0.54) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL7802850 | 0.82 | EGFR (0.66) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL7811115 | 0.81 | EGFR (0.60) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL7802802 | 0.81 | EGFR (0.66) | EGFRERBB2 | |
| Hydrochloric Acid SCHEMBL7809217 | 0.80 | EGFR (0.80) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL2099122 | 0.79 | EGFR (0.76) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL8427296 | 0.79 | EGFR (0.74) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL2988532 | 0.78 | EGFR (0.59) | EGFRERBB2MAPK1HTTHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0635498-B1 | Quinazoline derivatives and their use as anti-cancer agents | SYNGENTA LTD (GB) | 2001-04-18 | — | — | EP | disclosed |
| US-5475001-A | Quinazoline derivatives | ZENECA LIMITED (GB) | 1995-12-12 | — | — | US | disclosed |
| WO-1995003283-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS ANTI-CANCER AGENTS | ZENECA LIMITED (GB) | 1995-02-02 | — | — | WO | disclosed |
| EP-0635498-A1 | Quinazoline derivatives and their use as anti-cancer agents | ZENECA LIMITED (GB) | 1995-01-25 | — | — | EP | disclosed |