Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.77 |
| ▸ | SMO | Q99835 | 4/20 | 0.74 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7809434 | 0.93 | MAPK14 (0.66) | MAPK14SMOOPRK1 | |
| SCHEMBL6490264 | 0.88 | MAPK14 (0.58) | MAPK14SMOOPRK1CYP3A4CYP2C9 | |
| SCHEMBL6486278 | 0.86 | MAPK14 (1.00) | MAPK14SMO | |
| SCHEMBL6476258 | 0.84 | OPRK1 (0.62) | MAPK14SMOOPRK1 | |
| SCHEMBL6476055 | 0.83 | MAPK14 (0.67) | MAPK14SMOOPRK1 | |
| SCHEMBL6476859 | 0.81 | MAPK14 (0.55) | MAPK14SMOOPRK1CYP3A4CYP2C9 | |
| SCHEMBL2970301 | 0.80 | OPRK1 (0.61) | MAPK14SMOOPRK1 | |
| SCHEMBL6484951 | 0.80 | MAPK14 (0.60) | MAPK14SMOOPRK1 | |
| SCHEMBL6476195 | 0.79 | CSF1R (0.61) | MAPK14OPRK1 | |
| SCHEMBL27559756 | 0.79 | OPRK1 (0.53) | MAPK14SMOOPRK1MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077931-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | AstraZeneca AB (SE) | 2001-02-28 | — | — | EP | claimed |
| WO-1999059959-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 1999-11-25 | — | — | WO | claimed |
| EP-1077931-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | AstraZeneca AB (SE) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059959-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 1999-11-25 | — | — | WO | disclosed |