Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 17/20 | 0.63 |
| ▸ | EDNRB | P24530 | 14/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7817358 | 0.92 | EDNRA (0.78) | EDNRAEDNRB | |
| SCHEMBL8204303 | 0.84 | EDNRB (0.81) | EDNRAEDNRBMAPTMEN1ALDH1A1 | |
| SCHEMBL7817417 | 0.83 | EDNRA (0.66) | EDNRAEDNRB | |
| SCHEMBL7804297 | 0.79 | EDNRA (0.76) | EDNRAEDNRBMAPT | |
| SCHEMBL7561279 | 0.78 | EDNRB (1.00) | EDNRAEDNRB | |
| SCHEMBL8209842 | 0.78 | EDNRB (1.00) | EDNRAEDNRB | |
| SCHEMBL7561284 | 0.78 | EDNRB (1.00) | EDNRAEDNRB | |
| SCHEMBL7561291 | 0.78 | EDNRB (1.00) | EDNRAEDNRB | |
| SCHEMBL8202974 | 0.76 | EDNRB (0.78) | EDNRAEDNRB | |
| SCHEMBL8620446 | 0.75 | EDNRB (0.68) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612244-B1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2001-09-19 | — | — | EP | claimed |