Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.55 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.55 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.55 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.55 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.55 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.55 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.49 |
| ▸ | TUBB | P07437 | 2/20 | 0.49 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.49 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1579253 | 0.91 | KDM4E (0.52) | KDM4EALDH1A1HPGDGAANPSR1 | |
| SCHEMBL492550 | 0.81 | KDM4E (0.64) | KDM4EALDH1A1HPGDNPSR1GABRA1 | |
| SCHEMBL493081 | 0.81 | KDM4E (0.64) | KDM4EALDH1A1HPGDNPSR1GABRA1 | |
| SCHEMBL31507475 | 0.81 | KDM4E (0.64) | KDM4EALDH1A1HPGDNPSR1GABRA1 | |
| SCHEMBL27363663 | 0.80 | PRKAA1 (0.57) | KDM4EALDH1A1HPGDGAANPSR1 | |
| SCHEMBL12479871 | 0.80 | KDM4E (0.44) | KDM4EALDH1A1HPGDGAANPSR1 | |
| SCHEMBL20895120 | 0.79 | KDM4E (0.66) | KDM4EALDH1A1HPGDNPSR1POLB | |
| SCHEMBL10569944 | 0.78 | KDM4E (0.58) | KDM4EALDH1A1HPGDGAANPSR1 | |
| SCHEMBL12090413 | 0.78 | KDM4E (0.69) | KDM4EALDH1A1HPGDGAAPOLB | |
| SCHEMBL5479829 | 0.77 | PDE10A (0.52) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0792879-B1 | Process for preparing 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate | DAIICHI SEIYAKU CO (JP) | 2001-02-28 | — | — | EP | disclosed |
| US-5948913-A | A CRYSTAL OF 3-(2-(4-(3-CHLORO-2-METHYLPHENYL)-1-PIPERAZINYL)ETHYL)-5,6-DIM ETHOXY-1-(4-IMIDAZOLYLMETHYL)-1H-INDAZOLE DIHYDROCHLORIDE | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1999-09-07 | — | — | US | disclosed |
| US-5837706-A | CALMODULIN INHIBITOR FOR SUPPRESSION OF OF NEURONAL CELL DEATH | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1998-11-17 | — | — | US | disclosed |
| EP-0624584-B1 | Piperazine derivatives useful as calmodulin inhibitors | DAIICHI SEIYAKU CO (JP) | 1998-08-19 | — | — | EP | disclosed |
| US-5681954-A | HAS CALMODULIN INHIBITORY ACTIVITY; USEFUL IN TREATING DISEASES OF THE CIRCULATORY ORGANS OR IN CEREBRAL REGION | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1997-10-28 | — | — | US | disclosed |
| EP-0792879-A1 | HYDRATE FOR MEDICINAL USE | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1997-09-03 | — | — | EP | disclosed |
| US-5661150-A | Drug for neuroprotection | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1997-08-26 | — | — | US | disclosed |
| EP-0627219-A1 | Use of calmodulin inhibitors for neuroprotection | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1994-12-07 | — | — | EP | disclosed |
| EP-0624584-A1 | Piperazine derivatives useful as calmodolin inhibitors | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1994-11-17 | — | — | EP | disclosed |