SCHEMBL7809954

SCHEMBL7809954

CC(C)(Oc1cccc(C2CCN(C(=O)c3ccc(Cl)cc3)CC2)c1)C(=O)O

nearest known ligand 0.58

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
BCL9 O00512 10/20 0.58
CTNNB1 P35222 10/20 0.58
MGLL Q99685 3/20 0.53
PPARA Q07869 2/20 0.51
MEN1 O00255 1/20 0.49
KMT2A Q03164 1/20 0.49
HSD11B1 P28845 1/20 0.49
PARP10 Q53GL7 2/20 0.48
PARP14 Q460N5 1/20 0.48
FABP2 P12104 1/20 0.47
PPARG P37231 1/20 0.47
SLC22A12 Q96S37 1/20 0.47
MAPT P10636 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7813329 0.90 BCL9 (0.56) BCL9CTNNB1PPARAHSD11B1PARP10
SCHEMBL7810100 0.90 BCL9 (0.56) BCL9CTNNB1PPARAKMT2AHSD11B1
SCHEMBL7814025 0.90 HSD11B1 (0.63) BCL9CTNNB1PPARAHSD11B1PARP10
SCHEMBL7814100 0.90 BCL9 (0.56) BCL9CTNNB1PPARAMEN1KMT2A
SCHEMBL7817510 0.88 BCL9 (0.57) BCL9CTNNB1PPARAHSD11B1PARP10
SCHEMBL7811629 0.88 BCL9 (0.54) BCL9CTNNB1PPARAHSD11B1PARP10
SCHEMBL7814050 0.87 MEN1 (0.52) BCL9CTNNB1MGLLPPARAMEN1
SCHEMBL7817468 0.87 PPARA (0.57) MGLLPPARAMEN1KMT2AHSD11B1
SCHEMBL7817728 0.84 BCL9 (0.55) BCL9CTNNB1PPARAHSD11B1PARP10
SCHEMBL7811776 0.84 BCL9 (0.54) BCL9CTNNB1PPARAHSD11B1PARP10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0607536-B1 Arylamide derivatives SS PHARMACEUTICAL CO (JP) 2001-01-24 EP disclosed
US-5532371-A SIDE EFFECT REDUCTION SS PHARMACEUTICAL CO., LTD. (JP) 1996-07-02 US disclosed
US-5411972-A Arylamide derivatives for treating hyperlipemia SS PHARMACEUTICAL CO., LTD. (JP) 1995-05-02 US disclosed
EP-0607536-A1 Arylamide derivatives SS PHARMACEUTICAL CO., LTD. (JP) 1994-07-27 EP disclosed