Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 14/20 | 0.64 |
| ▸ | HTR1D | P28221 | 11/20 | 0.64 |
| ▸ | HTR1B | P28222 | 11/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.53 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.53 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7803707 | 0.84 | HTR1A (0.65) | HTR1AHTR1DHTR1BKCNH2SLC6A9 | |
| SCHEMBL7816693 | 0.84 | HTR1A (0.61) | HTR1AHTR1DHTR1BKCNH2SLC6A9 | |
| SCHEMBL7812375 | 0.84 | HTR1A (0.61) | HTR1AHTR1DHTR1BKCNH2SLC6A9 | |
| SCHEMBL7812482 | 0.83 | HTR1A (0.41) | HTR1AHTR1DHTR1BKCNH2SLC6A9 | |
| SCHEMBL6312894 | 0.82 | HTR1A (0.75) | HTR1AHTR1DHTR1BKCNH2SLC6A9 | |
| SCHEMBL7816650 | 0.81 | HTR1A (0.62) | HTR1AHTR1DHTR1BKCNH2SLC6A9 | |
| SCHEMBL7816510 | 0.80 | HTR1A (0.67) | HTR1AHTR1DHTR1BKCNH2SLC6A9 | |
| SCHEMBL7803798 | 0.80 | HTR1A (0.64) | HTR1AHTR1DHTR1BKCNH2SLC6A9 | |
| SCHEMBL7803565 | 0.79 | HTR1A (0.62) | HTR1AHTR1DHTR1BKCNH2SLC6A9 | |
| SCHEMBL8176301 | 0.79 | HTR1A (0.62) | HTR1AHTR1DHTR1BKCNH2SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0767782-B1 | ARYL AND HETEROARYL ALKOXYNAPHTHALENE DERIVATIVES | PFIZER (US) | 2001-10-31 | — | — | EP | disclosed |
| CN-1064350-C | Aryl and heteroaryl alkoxynaphtalene derivatives | PFIZER (US) | 2001-04-11 | — | — | CN | disclosed |
| US-6166020-A | Aryl and heteroaryl alkoxynaphthalene derivatives | PFIZER INC. (US) | 2000-12-26 | — | — | US | disclosed |
| CN-1151729-A | Aryl and heteroaryl alkoxynaphtalene derivatives | PFIZER (US) | 1997-06-11 | — | — | CN | disclosed |
| EP-0767782-A1 | ARYL AND HETEROARYL ALKOXYNAPHTHALENE DERIVATIVES | PFIZER INC. (US) | 1997-04-16 | — | — | EP | disclosed |
| WO-1996000720-A1 | ARYL AND HETEROARYL ALKOXYNAPHTHALENE DERIVATIVES | PFIZER INC. (US) | 1996-01-11 | — | — | WO | disclosed |