Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 15/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7802832 | 0.83 | ALOX5 (0.84) | ALOX5CYP3A4CYP2D6ALDH1A1MGAM | |
| SCHEMBL332442 | 0.83 | ALOX5 (1.00) | ALOX5PIK3CAMTORALDH1A1MGAM | |
| SCHEMBL29405839 | 0.83 | ALOX5 (1.00) | ALOX5PIK3CAMTORALDH1A1MGAM | |
| SCHEMBL7809205 | 0.82 | ALOX5 (0.75) | ALOX5CYP3A4ALDH1A1MGAMGAA | |
| SCHEMBL6571511 | 0.82 | ALOX5 (0.68) | ALOX5CYP3A4PIK3CAMTORALDH1A1 | |
| Hydrochloric Acid SCHEMBL8173877 | 0.82 | ALOX5 (0.98) | ALOX5ALDH1A1MGAMGAASI | |
| SCHEMBL8191374 | 0.82 | ALOX5 (0.80) | ALOX5CYP3A4CYP1A2CYP2D6CYP19A1 | |
| SCHEMBL8191373 | 0.82 | ALOX5 (0.80) | ALOX5CYP3A4CYP1A2CYP2D6CYP19A1 | |
| SCHEMBL7807420 | 0.82 | ALOX5 (0.77) | ALOX5CYP2C19ALDH1A1 | |
| SCHEMBL8173639 | 0.81 | ALOX5 (0.80) | ALOX5CYP3A4CYP2D6PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0787127-B1 | 5-LIPOXYGENASE INHIBITORS | PFIZER (US) | 2001-01-03 | — | — | EP | disclosed |
| US-6063928-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS, CARDIOTONIC AGENTS | PFIZER INC (US) | 2000-05-16 | — | — | US | disclosed |
| EP-0787127-A1 | 5-LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1997-08-06 | — | — | EP | disclosed |
| WO-1996011911-A1 | 5-LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1996-04-25 | — | — | WO | disclosed |