Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MGAM | O43451 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SI | P14410 | 1/20 | 0.44 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5925145 | 1.00 | HTR2A (0.52) | HTR2AHTR2CHTR2BGPR84NR4A2 | |
| SCHEMBL5925148 | 1.00 | HTR2A (0.52) | HTR2AHTR2CHTR2BGPR84NR4A2 | |
| SCHEMBL14542028 | 0.86 | HTR2A (0.54) | HTR2AHTR2CHTR2BGPR84FFAR1 | |
| SCHEMBL14542027 | 0.86 | HTR2A (0.54) | HTR2AHTR2CHTR2BGPR84FFAR1 | |
| SCHEMBL5913450 | 0.84 | HTR2A (0.48) | HTR2AHTR2CHTR2BGPR84NR4A2 | |
| SCHEMBL5913085 | 0.84 | GPR84 (0.53) | HTR2AHTR2CHTR2BGPR84FFAR1 | |
| SCHEMBL195995 | 0.84 | GPR84 (0.53) | HTR2AHTR2CHTR2BGPR84FFAR1 | |
| SCHEMBL9583795 | 0.84 | NR4A2 (0.53) | HTR2AHTR2CHTR2BGPR84NR4A2 | |
| SCHEMBL195996 | 0.84 | GPR84 (0.53) | HTR2AHTR2CHTR2BGPR84FFAR1 | |
| SCHEMBL18135252 | 0.84 | GPR84 (0.53) | HTR2AHTR2CHTR2BGPR84FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023061-A4 | SOMATOSTATIN AGONISTS | MERCK & CO INC (US) | 2001-04-11 | — | — | EP | disclosed |
| US-6117880-A | TREATMENT OF DIABETES, RETINOPATHY, RESTINOSIS, ACROMEGALY, AND DEPRESSION | MERCK & CO., INC. (US) | 2000-09-12 | — | — | US | disclosed |
| EP-1023061-A1 | SOMATOSTATIN AGONISTS | Merck & Co., Inc. (US) | 2000-08-02 | — | — | EP | disclosed |
| US-6063796-A | HETEROCYCLIC COMPOUNDS OF PIPERIDINE | MERCK & CO., INC. (US) | 2000-05-16 | — | — | US | disclosed |
| EP-0984779-A4 | SOMATOSTATIN AGONISTS | MERCK & CO INC (US) | 2000-05-10 | — | — | EP | disclosed |
| US-6057338-A | USEFUL IN THE TREATMENT OF DIABETES, CANCER, ACROMEGALY, RESTENOSIS, DEPRESSION, IRRITABLE BOWEL SYNDROME, PAIN AND DIABETIC RETINOPATHY | MERCK & CO., INC. (US) | 2000-05-02 | — | — | US | disclosed |
| EP-0977751-A4 | SOMATOSTATIN AGONISTS | MERCK & CO INC (US) | 2000-04-26 | — | — | EP | disclosed |
| EP-0984779-A1 | SOMATOSTATIN AGONISTS | Merck & Co., Inc. (US) | 2000-03-15 | — | — | EP | disclosed |
| US-6025372-A | Somatostatin agonists | MERCK & CO., INC. (US) | 2000-02-15 | — | — | US | disclosed |
| EP-0977751-A1 | SOMATOSTATIN AGONISTS | Merck & Co., Inc. (US) | 2000-02-09 | — | — | EP | disclosed |
| WO-1999022735-A1 | SOMATOSTATIN AGONISTS | MERCK & CO., INC. (US) | 1999-05-14 | — | — | WO | disclosed |
| WO-1998044921-A1 | SOMATOSTATIN AGONISTS | MERCK & CO., INC. (US) | 1998-10-15 | — | — | WO | disclosed |
| WO-1998044922-A1 | SOMATOSTATIN AGONISTS | MERCK & CO., INC. (US) | 1998-10-15 | — | — | WO | disclosed |
| WO-1998045285-A1 | SOMATOSTATIN AGONISTS | MERCK & CO., INC. (US) | 1998-10-15 | — | — | WO | disclosed |