Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 12/20 | 0.75 |
| ▸ | HTR1B | P28222 | 11/20 | 0.75 |
| ▸ | HTR1A | P08908 | 9/20 | 0.75 |
| ▸ | HTR2A | P28223 | 5/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.75 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.75 |
| ▸ | HTR1F | P30939 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.46 |
| ▸ | MPO | P05164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5528416 | 1.00 | HTR1D (0.75) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| SCHEMBL7811321 | 1.00 | HTR1D (0.75) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| SCHEMBL8091337 | 0.89 | HTR1D (0.75) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| SCHEMBL8091339 | 0.89 | HTR1D (0.75) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| SCHEMBL2617889 | 0.89 | HTR1D (0.78) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| SCHEMBL2739219 | 0.86 | HTR1D (0.74) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| Zolmitriptan SCHEMBL40595 | 0.86 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| Zolmitriptan SCHEMBL4427888 | 0.86 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| Zolmitriptan SCHEMBL33336 | 0.86 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2AKMT2A | |
| SCHEMBL7817210 | 0.86 | HTR1D (0.74) | HTR1DHTR1BHTR1AHTR2AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636623-B1 | Indole derivatives as 5-HT1- like agonists | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | EP | disclosed |
| EP-0486666-B1 | THERAPEUTIC HETEROCYCLIC COMPOUNDS | ZENECA LTD (GB) | 1997-08-13 | — | — | EP | disclosed |
| US-5466699-A | Indolyl compounds for treating migraine | BURROUGHS WELLCOME CO. (US) | 1995-11-14 | — | — | US | disclosed |
| US-5399574-A | 5-hydroxytryptamine agonists; vasoconstrictors | BURROUGHS WELLCOME CO. (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0636623-A1 | Indole derivatives as 5-HT1- like agonists | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-02-01 | — | — | EP | disclosed |