Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | PARP1 | P09874 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.52 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.52 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.52 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.52 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7350621 | 0.79 | DAO (0.65) | LMNAPARP1HPGDKDM4EMEN1 | |
| SCHEMBL9086944 | 0.79 | LMNA (0.70) | LMNAPARP1HPGDKDM4EMEN1 | |
| SCHEMBL31378780 | 0.79 | DAO (0.64) | PARP1MAPK1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL1270149 | 0.77 | CYP1A2 (0.56) | LMNAPARP1HPGDKDM4EMEN1 | |
| SCHEMBL8874832 | 0.76 | PARP1 (0.75) | LMNAPARP1HPGDKDM4EMEN1 | |
| SCHEMBL7346243 | 0.76 | TYMS (0.50) | LMNAPARP1HPGDKDM4EMAPK1 | |
| SCHEMBL7802847 | 0.76 | LMNA (0.59) | LMNAPARP1HPGDKDM4EMEN1 | |
| SCHEMBL7802763 | 0.76 | LMNA (0.59) | LMNAPARP1HPGDKDM4EMEN1 | |
| SCHEMBL31378871 | 0.75 | DAO (0.64) | LMNAPARP1KDM4EMEN1MAPK1 | |
| SCHEMBL20693897 | 0.75 | LMNA (0.64) | LMNAPARP1HPGDKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0644878-B1 | 2,5-DIOXO-2,5-DIHYDRO-1H-BENZ b]AZEPINES AS NMDA RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2001-09-12 | — | — | EP | claimed |
| US-5492905-A | NERVOUS SYSTEM DISORDERS | ZENECA LIMITED (GB) | 1996-02-20 | — | — | US | claimed |
| EP-0644878-A1 | 2,5-DIOXO-2,5-DIHYDRO-1H-BENZ b]AZEPINES AS NMDA RECEPTOR ANTAGONISTS | ZENECA LIMITED (GB) | 1995-03-29 | — | — | EP | claimed |
| WO-1993025534-A1 | 2,5-DIOXO-2,5-DIHYDRO-1H-BENZ[b]AZEPINES AS NMDA RECEPTOR ANTAGONISTS | ZENECA LIMITED (GB) | 1993-12-23 | — | — | WO | claimed |
| EP-0644878-B1 | 2,5-DIOXO-2,5-DIHYDRO-1H-BENZ b]AZEPINES AS NMDA RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2001-09-12 | — | — | EP | disclosed |
| US-5712272-A | TREATMENT OF NEUROLOGICAL DISORDERS WITH BENZ(B)AZEPINE COMPOUNDS | ZENECA LIMITED (GB) | 1998-01-27 | — | — | US | disclosed |
| US-5654295-A | NEUROLOGICAL DISORDERS; BENZ(B0AZEPINE COMPOUNDS | ZENECA LIMITED (GB) | 1997-08-05 | — | — | US | disclosed |
| US-5492905-A | NERVOUS SYSTEM DISORDERS | ZENECA LIMITED (GB) | 1996-02-20 | — | — | US | disclosed |
| EP-0644878-A1 | 2,5-DIOXO-2,5-DIHYDRO-1H-BENZ b]AZEPINES AS NMDA RECEPTOR ANTAGONISTS | ZENECA LIMITED (GB) | 1995-03-29 | — | — | EP | disclosed |
| WO-1993025534-A1 | 2,5-DIOXO-2,5-DIHYDRO-1H-BENZ[b]AZEPINES AS NMDA RECEPTOR ANTAGONISTS | ZENECA LIMITED (GB) | 1993-12-23 | — | — | WO | disclosed |