Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 13/20 | 0.42 |
| ▸ | ECE1 | P42892 | 1/20 | 0.42 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SNCA | P37840 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7810464 | 0.96 | TOP2A (0.42) | TOP2AECE1MUS81KDM4CBRCA1 | |
| SCHEMBL7804809 | 0.95 | ECE1 (0.47) | TOP2AECE1MUS81KDM4CSMN1; SMN2 | |
| SCHEMBL7804758 | 0.92 | TOP2A (0.43) | TOP2AECE1MUS81TDP2TDP1 | |
| SCHEMBL7804602 | 0.91 | ECE1 (0.47) | TOP2AECE1MUS81KDM4CTDP2 | |
| SCHEMBL7810337 | 0.91 | TOP2A (0.43) | TOP2AECE1MUS81SMN1; SMN2LMNA | |
| SCHEMBL7817250 | 0.90 | TOP2A (0.44) | TOP2AECE1MUS81BRCA1SMN1; SMN2 | |
| SCHEMBL7810277 | 0.89 | TOP2A (0.42) | TOP2AECE1MUS81TDP2TDP1 | |
| SCHEMBL7814689 | 0.89 | TOP2A (0.45) | TOP2AECE1MUS81KDM4CBRCA1 | |
| SCHEMBL7810513 | 0.88 | TOP2A (0.43) | TOP2AECE1MUS81TDP2TDP1 | |
| SCHEMBL7810397 | 0.88 | TOP2A (0.57) | TOP2AECE1MUS81SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0662076-B1 | 2-AMINOALKYL-5-AMINOALKYLAMINO SUBSTITUTED ISOQUINOINDAZOLE-6-(2H)-ONES WITH ANTITUMOUR ACTIVITY | UNIV VERMONT (US) | 2001-04-11 | — | — | EP | claimed |
| EP-0750619-A1 | HETERO-ANNULATED INDAZOLES | BOEHRINGER MANNHEIM ITALIA S.p.A. (IT) | 1997-01-02 | — | — | EP | claimed |
| WO-1995024407-A1 | HETERO-ANNULATED INDAZOLES | BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) | 1995-09-14 | — | — | WO | claimed |
| WO-1994006795-A1 | 2-AMINOALKYL-5-AMINOALKYLAMINO SUBSTITUTED ISOQUINOINDAZOLE-6-(2H)-ONES WITH ANTITUMOUR ACTIVITY | THE UNIVERSITY OF VERMONT (US) | 1994-03-31 | — | — | WO | claimed |
| EP-0662076-B1 | 2-AMINOALKYL-5-AMINOALKYLAMINO SUBSTITUTED ISOQUINOINDAZOLE-6-(2H)-ONES WITH ANTITUMOUR ACTIVITY | UNIV VERMONT (US) | 2001-04-11 | — | — | EP | disclosed |
| US-5604246-A | HAVING POTENCY AGAINST MULTIDRUG RESISTANT TUMORS | BOEHRINGER MANNHEIM ITALIA SPA (IT) | 1997-02-18 | — | — | US | disclosed |
| US-5519029-A | ANTITUMOR AGENTS | BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) | 1996-05-21 | — | — | US | disclosed |
| WO-1995024407-A1 | HETERO-ANNULATED INDAZOLES | BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) | 1995-09-14 | — | — | WO | disclosed |
| WO-1994006795-A1 | 2-AMINOALKYL-5-AMINOALKYLAMINO SUBSTITUTED ISOQUINOINDAZOLE-6-(2H)-ONES WITH ANTITUMOUR ACTIVITY | THE UNIVERSITY OF VERMONT (US) | 1994-03-31 | — | — | WO | disclosed |