Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 13/20 | 0.43 |
| ▸ | ECE1 | P42892 | 1/20 | 0.37 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.37 |
| ▸ | TDP2 | O95551 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | BLM | P54132 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7808820 | 0.96 | TOP2A (0.43) | TOP2AECE1MUS81TDP2TDP1 | |
| SCHEMBL7804758 | 0.93 | TOP2A (0.43) | TOP2AECE1MUS81TDP2TDP1 | |
| SCHEMBL7812036 | 0.93 | TOP2A (0.43) | TOP2AECE1MUS81TDP2TDP1 | |
| SCHEMBL7804806 | 0.91 | TOP2A (0.48) | TOP2AECE1MUS81MAPTBLM | |
| SCHEMBL7811784 | 0.91 | TOP2A (0.42) | TOP2AECE1MUS81TDP2TDP1 | |
| SCHEMBL7804809 | 0.91 | ECE1 (0.47) | TOP2AECE1MUS81TDP2TDP1 | |
| SCHEMBL7810513 | 0.90 | TOP2A (0.43) | TOP2AECE1MUS81TDP2TDP1 | |
| SCHEMBL7810397 | 0.89 | TOP2A (0.57) | TOP2AECE1MUS81TDP1MAPT | |
| SCHEMBL7817250 | 0.88 | TOP2A (0.44) | TOP2AECE1MUS81TDP2TDP1 | |
| SCHEMBL7811757 | 0.88 | TOP2A (0.48) | TOP2AECE1MUS81MAPTBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0662076-B1 | 2-AMINOALKYL-5-AMINOALKYLAMINO SUBSTITUTED ISOQUINOINDAZOLE-6-(2H)-ONES WITH ANTITUMOUR ACTIVITY | UNIV VERMONT (US) | 2001-04-11 | — | — | EP | claimed |
| WO-1994006795-A1 | 2-AMINOALKYL-5-AMINOALKYLAMINO SUBSTITUTED ISOQUINOINDAZOLE-6-(2H)-ONES WITH ANTITUMOUR ACTIVITY | THE UNIVERSITY OF VERMONT (US) | 1994-03-31 | — | — | WO | claimed |
| EP-0662076-B1 | 2-AMINOALKYL-5-AMINOALKYLAMINO SUBSTITUTED ISOQUINOINDAZOLE-6-(2H)-ONES WITH ANTITUMOUR ACTIVITY | UNIV VERMONT (US) | 2001-04-11 | — | — | EP | disclosed |
| US-5604246-A | HAVING POTENCY AGAINST MULTIDRUG RESISTANT TUMORS | BOEHRINGER MANNHEIM ITALIA SPA (IT) | 1997-02-18 | — | — | US | disclosed |
| US-5596097-A | ANTITUMOR AGENTS | THE UNIVERSITY OF VERMONT (US) | 1997-01-21 | — | — | US | disclosed |