Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 4/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12075817 | 0.96 | TAAR1 (0.52) | MAOATAAR1HRH1HTR2ATLR8 | |
| SCHEMBL12075818 | 0.94 | MAOA (0.43) | MAOATAAR1HRH1HTR2ATLR8 | |
| SCHEMBL12075401 | 0.94 | HTR2A (0.44) | MAOATAAR1HRH1HTR2ATLR8 | |
| SCHEMBL12062435 | 0.92 | MAOA (0.42) | MAOATAAR1HRH1HTR2ATLR8 | |
| SCHEMBL12075683 | 0.90 | MAOA (0.41) | MAOATAAR1HRH1HTR2ATLR8 | |
| SCHEMBL12075862 | 0.90 | MAOA (0.41) | MAOATAAR1HRH1HTR2ATLR8 | |
| SCHEMBL12075878 | 0.90 | MAOA (0.41) | MAOATAAR1HRH1HTR2ATLR8 | |
| SCHEMBL17277559 | 0.90 | MAOA (0.41) | MAOATAAR1HRH1HTR2ATLR8 | |
| SCHEMBL12075485 | 0.90 | MAOA (0.41) | MAOATAAR1HRH1HTR2ATLR8 | |
| SCHEMBL7436821 | 0.87 | MAOA (0.59) | MAOAHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690055-B1 | Stereoselective process for making endo-tropanamine and like compounds | LILLY CO ELI (US) | 2001-11-14 | — | — | EP | disclosed |
| US-5625065-A | Stereoselective process for making endo-tropanamine and like compounds | ELI LILLY AND COMPANY (US) | 1997-04-29 | — | — | US | disclosed |
| EP-0690055-A1 | Stereoselective process for making endo-tropanamine and like compounds | ELI LILLY AND COMPANY (US) | 1996-01-03 | — | — | EP | disclosed |