Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27622754 | 0.83 | ATM (0.34) | TSHRHPGDHCAR2ATMALDH1A1 | |
| SCHEMBL27520966 | 0.83 | ATM (0.34) | TSHRHPGDHCAR2ATMALDH1A1 | |
| Hydrochloric Acid SCHEMBL8564310 | 0.78 | SLC1A2 (0.33) | HCAR2ATM | |
| SCHEMBL27930505 | 0.76 | ATM (0.36) | TSHRHPGDHCAR2ATMALDH1A1 | |
| SCHEMBL7621106 | 0.74 | CPA1 (0.33) | — | |
| SCHEMBL27654740 | 0.74 | ATM (0.34) | TSHRHPGDHCAR2ATMALDH1A1 | |
| SCHEMBL2966906 | 0.73 | TSHR (0.44) | TSHRHPGDHCAR2ATMALDH1A1 | |
| SCHEMBL2966900 | 0.73 | TSHR (0.44) | TSHRHPGDHCAR2ATMALDH1A1 | |
| SCHEMBL27452646 | 0.70 | CA1 (0.34) | TSHRHPGDATMALDH1A1 | |
| SCHEMBL13864541 | 0.69 | CA2 (0.37) | TSHRHPGDHCAR2ATMPLA2G2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1068304-A4 | TREATMENT OF PARASITIC DISEASES BY INHIBITION OF CYSTEINE PROTEASES OF THE PAPAIN SUPERFAMILY | SMITHKLINE BEECHAM CORP (US) | 2001-05-09 | — | — | EP | disclosed |
| EP-1068304-A1 | TREATMENT OF PARASITIC DISEASES BY INHIBITION OF CYSTEINE PROTEASES OF THE PAPAIN SUPERFAMILY | SMITHKLINE BEECHAM CORPORATION (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999053039-A1 | TREATMENT OF PARASITIC DISEASES BY INHIBITION OF CYSTEINE PROTEASES OF THE PAPAIN SUPERFAMILY | SMITHKLINE BEECHAM CORPORATION (US) | 1999-10-21 | — | — | WO | disclosed |