Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 13/20 | 0.67 |
| ▸ | HTR1D | P28221 | 11/20 | 0.67 |
| ▸ | HTR1B | P28222 | 11/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.55 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6306206 | 0.88 | HTR1A (0.66) | HTR1AHTR1DHTR1BKCNH2SLC6A9 | |
| SCHEMBL7816701 | 0.87 | HTR1A (0.61) | HTR1AHTR1DHTR1BKCNH2SLC6A9 | |
| SCHEMBL7812227 | 0.82 | HTR1A (0.60) | HTR1AHTR1DHTR1BKCNH2SLC6A9 | |
| SCHEMBL7812815 | 0.81 | HTR1A (0.62) | HTR1AHTR1DHTR1BKCNH2SLC6A9 | |
| SCHEMBL7803546 | 0.81 | HTR1A (0.42) | HTR1AHTR1DHTR1BKCNH2SLC6A9 | |
| SCHEMBL6312894 | 0.81 | HTR1A (0.75) | HTR1AHTR1DHTR1BKCNH2SLC6A9 | |
| SCHEMBL7803557 | 0.80 | HTR1A (0.64) | HTR1AHTR1DHTR1BKCNH2SLC6A9 | |
| SCHEMBL8192702 | 0.80 | HTR1A (0.70) | HTR1AHTR1DHTR1BKCNH2SLC6A9 | |
| SCHEMBL7812400 | 0.80 | HTR1A (0.60) | HTR1AHTR1DHTR1BKCNH2SLC6A9 | |
| SCHEMBL7812331 | 0.80 | HTR1A (0.60) | HTR1AHTR1DHTR1BKCNH2SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0767782-B1 | ARYL AND HETEROARYL ALKOXYNAPHTHALENE DERIVATIVES | PFIZER (US) | 2001-10-31 | — | — | EP | disclosed |
| US-6166020-A | Aryl and heteroaryl alkoxynaphthalene derivatives | PFIZER INC. (US) | 2000-12-26 | — | — | US | disclosed |
| EP-0767782-A1 | ARYL AND HETEROARYL ALKOXYNAPHTHALENE DERIVATIVES | PFIZER INC. (US) | 1997-04-16 | — | — | EP | disclosed |
| WO-1996000720-A1 | ARYL AND HETEROARYL ALKOXYNAPHTHALENE DERIVATIVES | PFIZER INC. (US) | 1996-01-11 | — | — | WO | disclosed |