Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.36 |
| ▸ | RXRA | P19793 | 4/20 | 0.36 |
| ▸ | RXRB | P28702 | 3/20 | 0.36 |
| ▸ | RXRG | P48443 | 2/20 | 0.36 |
| ▸ | SMYD2 | Q9NRG4 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9342265 | 0.85 | RXRA (0.51) | PPARGRXRARXRBRXRGNR4A2 | |
| SCHEMBL9347235 | 0.84 | ESR1 (0.43) | PPARGALDH1A1ATM | |
| SCHEMBL1314001 | 0.84 | AGXT (0.42) | SMYD2ALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL5918964 | 0.84 | MAOB (0.50) | PPARGRXRARXRBRXRGALDH1A1 | |
| SCHEMBL2745018 | 0.83 | PPARG (0.41) | PPARGRXRARXRBRXRGPPARA | |
| SCHEMBL14542685 | 0.81 | AGXT (0.43) | CA1CA2CA9ALDH1A1HTT | |
| SCHEMBL11934179 | 0.81 | TP53 (0.42) | PPARGRXRARXRBSMYD2PPARA | |
| SCHEMBL9347236 | 0.80 | AGXT (0.33) | PPARGRXRARXRBRXRGSMYD2 | |
| SCHEMBL4587307 | 0.80 | IDO1 (0.42) | HTTSMN1; SMN2L3MBTL1MAOB | |
| SCHEMBL222047 | 0.80 | MAOB (0.43) | SMN1; SMN2L3MBTL1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0574784-B1 | Process for preparing (1'R,3S,4R)4-acylthio azetidinones | PHARMACIA & UPJOHN SPA (IT) | 2001-12-05 | — | — | EP | disclosed |
| US-5399679-A | (1'R,3S,4R)4-acylthio azetidinones | FARMITALIA CARLO ERBA S.R.L. (IT) | 1995-03-21 | — | — | US | disclosed |
| WO-1993025523-A1 | 4-ACYLTHIO AZETIDINONES | FARMITALIA CARLO ERBA S.R.L. (IT) | 1993-12-23 | — | — | WO | disclosed |
| EP-0574784-A1 | (1'R,3S,4R)4-acylthio azetidinones | PHARMACIA S.p.A. (IT) | 1993-12-22 | — | — | EP | disclosed |