Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 5/20 | 0.46 |
| ▸ | CDK2 | P24941 | 3/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | MTOR | P42345 | 2/20 | 0.46 |
| ▸ | SMG1 | Q96Q15 | 2/20 | 0.46 |
| ▸ | CDK4 | P11802 | 2/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.46 |
| ▸ | CCND1 | P24385 | 2/20 | 0.46 |
| ▸ | CDK7 | P50613 | 2/20 | 0.46 |
| ▸ | CCNH | P51946 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | XBP1 | P17861 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7813343 | 0.90 | CDK1 (0.48) | CDK1CDK2CDK5CDK5R1MAPK1 | |
| SCHEMBL7817227 | 0.89 | CDK1 (0.49) | CDK1CDK2CDK5CDK5R1MAPK1 | |
| SCHEMBL7817087 | 0.83 | CDK1 (0.56) | CDK1CDK2CDK5CDK5R1MAPK1 | |
| SCHEMBL7810018 | 0.78 | CDK1 (0.54) | CDK1CDK2CDK5CDK5R1MAPK1 | |
| SCHEMBL7814021 | 0.78 | KARS1 (0.49) | CDK1CDK2CDK5CDK5R1MAPK1 | |
| SCHEMBL7813871 | 0.76 | CDK1 (0.61) | CDK1CDK2CDK5CDK5R1MAPK1 | |
| SCHEMBL7813762 | 0.76 | CDK1 (0.51) | CDK1CDK2CDK5CDK5R1MAPK1 | |
| SCHEMBL7811116 | 0.74 | CDK1 (0.66) | CDK1CDK2CDK5CDK5R1MAPK1 | |
| SCHEMBL7817275 | 0.70 | CDK1 (0.50) | CDK1CDK2CDK5CDK5R1MAPK1 | |
| SCHEMBL7804339 | 0.70 | MAPK1 (0.40) | CDK1CDK2CDK5CDK5R1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0672041-B1 | PHARMACOLOGICALLY ACTIVE PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 2001-11-14 | — | — | EP | disclosed |
| EP-0672041-A1 | PHARMACOLOGICALLY ACTIVE PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | Novartis AG (CH) | 1995-09-20 | — | — | EP | disclosed |
| WO-1995009853-A1 | PHARMACOLOGICALLY ACTIVE PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | CIBA-GEIGY AG (CH) | 1995-04-13 | — | — | WO | disclosed |