Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 8/20 | 0.62 |
| ▸ | MMP2 | P08253 | 3/20 | 0.50 |
| ▸ | MMP9 | P14780 | 3/20 | 0.50 |
| ▸ | MMP8 | P22894 | 3/20 | 0.50 |
| ▸ | TNKS | O95271 | 3/20 | 0.49 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.49 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.49 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.48 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.45 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CASP3 | P42574 | 2/20 | 0.44 |
| ▸ | MMP13 | P45452 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6581039 | 0.89 | MAPT (0.51) | PARP1MMP2MMP9MMP8HPSE | |
| SCHEMBL6585358 | 0.83 | PKN1 (0.58) | PARP1PARP2HPSEPKN1PKN2 | |
| SCHEMBL7815539 | 0.81 | PARP1 (0.57) | PARP1MMP2MMP9MMP8TNKS | |
| SCHEMBL28425038 | 0.80 | TNKS (0.72) | PARP1MMP2MMP9MMP8TNKS | |
| SCHEMBL7319465 | 0.77 | PARP1 (1.00) | PARP1PARP2PKN1PKN2CHEK2 | |
| SCHEMBL29411909 | 0.77 | PARP1 (1.00) | PARP1PARP2PKN1PKN2CHEK2 | |
| SCHEMBL6582804 | 0.76 | HPSE (0.47) | PARP1PARP2HPSEPKN1PKN2 | |
| SCHEMBL7484761 | 0.76 | HPSE (0.43) | PARP1HPSEPKN1PKN2DHODH | |
| SCHEMBL6584459 | 0.74 | MAP4K4 (0.69) | PARP1HPSEPKN2DHODHPLA2G2A | |
| SCHEMBL6330691 | 0.74 | PARP1 (0.70) | PARP1MMP2MMP9MMP8TNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1127052-A1 | SUBSTITUTED 2-PHENYLBENZIMIDAZOLES, THE PRODUCTION THEREOF AND THEIR USE | BASF AKTIENGESELLSCHAFT (DE) | 2001-08-29 | — | — | EP | disclosed |
| WO-2000026192-A1 | SUBSTITUTED 2-PHENYLBENZIMIDAZOLES, THE PRODUCTION THEREOF AND THEIR USE | BASF AKTIENGESELLSCHAFT (DE) | 2000-05-11 | — | — | WO | disclosed |