Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 3/20 | 0.47 |
| ▸ | PARP1 | P09874 | 7/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.42 |
| ▸ | PKN1 | Q16512 | 3/20 | 0.41 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6578697 | 0.89 | HPSE (0.47) | HPSEPARP1PARP2PKN1PKN2 | |
| SCHEMBL6583754 | 0.83 | KDM4E (0.47) | HPSEPARP1PARP2PKN1PKN2 | |
| SCHEMBL6585358 | 0.83 | PKN1 (0.58) | HPSEPARP1PARP2PKN1PKN2 | |
| SCHEMBL3585590 | 0.83 | PKN1 (0.54) | PARP1PARP2PKN1PKN2AURKB | |
| SCHEMBL3575386 | 0.79 | PARP1 (0.67) | PARP1PARP2PKN1PKN2AURKB | |
| SCHEMBL7813883 | 0.76 | PARP1 (0.62) | HPSEPARP1PARP2PKN1PKN2 | |
| SCHEMBL3577852 | 0.74 | AURKB (0.61) | PARP1PARP2PKN1PKN2AURKB | |
| SCHEMBL6584459 | 0.72 | MAP4K4 (0.69) | HPSEPARP1PKN2AURKBDYRK3 | |
| SCHEMBL7484761 | 0.72 | HPSE (0.43) | HPSEPARP1PKN1PKN2DHODH | |
| SCHEMBL6581039 | 0.71 | MAPT (0.51) | HPSEPARP1KDM4ENPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1391457-B1 | Substituted 2-Phenylbenzimidazoles and their use as PARP inhibitors | ABBVIE DEUTSCHLAND (DE) | 2013-12-25 | — | — | EP | disclosed |
| EP-1127052-B1 | SUBSTITUTED 2-PHENYLBENZIMIDAZOLES, THE PRODUCTION THEREOF AND THEIR USE | ABBOTT GMBH & CO KG (DE) | 2004-12-08 | — | — | EP | disclosed |
| EP-1391457-A1 | Substituted 2-Phenylbenzimidazoles and their use as PARP inhibitors | Abbott GmbH & Co. KG (DE) | 2004-02-25 | — | — | EP | disclosed |