Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10588674 | 0.74 | KCNN4 (0.41) | KCNN4TSHRALDH1A1TAAR1CYP1A2 | |
| SCHEMBL439212 | 0.74 | KIF11 (0.46) | KCNN4TSHRALDH1A1TAAR1CYP1A2 | |
| SCHEMBL20534911 | 0.72 | CYP2C19 (0.46) | KCNN4TSHRALDH1A1TAAR1CYP1A2 | |
| SCHEMBL28444007 | 0.72 | CYP2C19 (0.41) | KCNN4TSHRALDH1A1TAAR1CYP1A2 | |
| SCHEMBL10830860 | 0.72 | TDP1 (0.42) | KCNN4TSHRALDH1A1TAAR1CYP1A2 | |
| SCHEMBL11816290 | 0.72 | KCNN4 (0.39) | KCNN4TSHRALDH1A1TAAR1CYP1A2 | |
| SCHEMBL6682491 | 0.72 | KCNN4 (0.46) | KCNN4TSHRALDH1A1TAAR1CYP1A2 | |
| SCHEMBL5968241 | 0.70 | CYP1A2 (0.56) | TSHRALDH1A1ATMTAAR1CYP1A2 | |
| SCHEMBL1720942 | 0.70 | TAAR1 (0.58) | KCNN4TSHRALDH1A1TAAR1CYP2C19 | |
| SCHEMBL4864723 | 0.70 | KCNN4 (0.39) | KCNN4TSHRALDH1A1ATMTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1124804-A1 | PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE BIOSYNTHESIS INHIBITORS | ABBOTT LABORATORIES (US) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000024719-A1 | PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE BIOSYNTHESIS INHIBITORS | ABBOTT LABORATORIES (US) | 2000-05-04 | — | — | WO | disclosed |