Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPFFR2 | Q9Y5X5 | 3/20 | 0.47 |
| ▸ | NPFFR1 | Q9GZQ6 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | APP | P05067 | 2/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.38 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 6/20 | 0.36 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7814664 | 1.00 | NPFFR2 (0.47) | NPFFR2NPFFR1KDRHDAC1HDAC8 | |
| SCHEMBL18420271 | 0.81 | NPFFR1 (0.48) | NPFFR2NPFFR1KDRHDAC1HDAC8 | |
| SCHEMBL18420270 | 0.81 | NPFFR1 (0.48) | NPFFR2NPFFR1KDRHDAC1HDAC8 | |
| SCHEMBL7807626 | 0.78 | CHAT (0.50) | NPFFR2 | |
| SCHEMBL7807620 | 0.78 | CHAT (0.50) | NPFFR2 | |
| SCHEMBL2096623 | 0.77 | NPFFR2 (0.50) | NPFFR2NPFFR1KDRHDAC1HDAC8 | |
| SCHEMBL2096625 | 0.77 | NPFFR2 (0.50) | NPFFR2NPFFR1KDRHDAC1HDAC8 | |
| SCHEMBL46855 | 0.74 | NPFFR2 (0.54) | NPFFR2NPFFR1KDRHDAC1HDAC8 | |
| SCHEMBL9005576 | 0.73 | NPFFR2 (0.47) | NPFFR2NPFFR1KDRHDAC1HDAC8 | |
| SCHEMBL2325457 | 0.73 | NPFFR2 (0.50) | NPFFR2NPFFR1KDRHDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0650480-B1 | 1-ARYLSULPHONYL-3-PHENYL-1,4,5,6-TETRAHYDROPYRIDAZINES | ORTHO PHARMA CORP (US) | 2001-11-21 | — | — | EP | disclosed |
| US-5684151-A | PROGESTIN AGONISTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-11-04 | — | — | US | disclosed |
| EP-0650480-A1 | 1-ARYLSULPHONYL, ARYLCARBONYL AND 1-ARYLPHOSPHONYL-3-PHENYL-1,4,5,6-TETRAHYDROPYRIDAZINES | ORTHO PHARMACEUTICAL CORPORATION (US) | 1995-05-03 | — | — | EP | disclosed |
| WO-1994001412-A1 | 1-ARYLSULPHONYL, ARYLCARBONYL AND 1-ARYLPHOSPHONYL-3-PHENYL-1,4,5,6-TETRAHYDROPYRIDAZINES | ORTHO PHARMACEUTICAL CORPORATION (US) | 1994-01-20 | — | — | WO | disclosed |