Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | CES2 | O00748 | 1/20 | 0.54 |
| ▸ | CES1 | P23141 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.52 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7814739 | 1.00 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2CES2CES1 | |
| SCHEMBL7922898 | 0.88 | CES2 (0.57) | NPC1RAB9ASMN1; SMN2CES2CES1 | |
| SCHEMBL7922894 | 0.88 | CES2 (0.57) | NPC1RAB9ASMN1; SMN2CES2CES1 | |
| SCHEMBL9933244 | 0.84 | TRPV1 (0.53) | NPC1RAB9ASMN1; SMN2CES2CES1 | |
| SCHEMBL9933246 | 0.84 | TRPV1 (0.53) | NPC1RAB9ASMN1; SMN2CES2CES1 | |
| SCHEMBL7813930 | 0.82 | NR4A2 (0.48) | SMN1; SMN2CES2CES1MEN1KMT2A | |
| SCHEMBL10471632 | 0.82 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2CES2CES1 | |
| SCHEMBL8512457 | 0.81 | KMT2A (0.49) | NPC1RAB9ASMN1; SMN2CES2CES1 | |
| SCHEMBL8512454 | 0.81 | KMT2A (0.49) | NPC1RAB9ASMN1; SMN2CES2CES1 | |
| SCHEMBL30542256 | 0.81 | CES2 (0.68) | NPC1RAB9ASMN1; SMN2CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091958-A1 | SALTS OF PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000001692-A1 | SALTS OF PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 2000-01-13 | — | — | WO | disclosed |