Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 5/20 | 0.36 |
| ▸ | MMP2 | P08253 | 7/20 | 0.34 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.34 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.34 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 6/20 | 0.32 |
| ▸ | MMP7 | P09237 | 4/20 | 0.32 |
| ▸ | LTA4H | P09960 | 2/20 | 0.32 |
| ▸ | ANPEP | P15144 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 5/20 | 0.32 |
| ▸ | MMP8 | P22894 | 2/20 | 0.32 |
| ▸ | MMP9 | P14780 | 2/20 | 0.32 |
| ▸ | MMP14 | P50281 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | MMP12 | P39900 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | FCER2 | P06734 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7812013 | 1.00 | ADAM17 (0.36) | ADAM17MMP2ERAP2ERAP1LNPEP | |
| Hydrochloric Acid SCHEMBL6984681 | 0.99 | ADAM17 (0.35) | ADAM17MMP2ERAP2ERAP1LNPEP | |
| Hydrochloric Acid SCHEMBL6984476 | 0.99 | ADAM17 (0.35) | ADAM17MMP2ERAP2ERAP1LNPEP | |
| Hydrochloric Acid SCHEMBL6986403 | 0.90 | ADAM17 (0.38) | ADAM17MMP2MMP3MMP7LTA4H | |
| Hydrochloric Acid SCHEMBL6984713 | 0.90 | ADAM17 (0.38) | ADAM17MMP2MMP3MMP7LTA4H | |
| Hydrochloric Acid SCHEMBL6986535 | 0.88 | ADAM17 (0.37) | ADAM17MMP2MMP3MMP7LTA4H | |
| SCHEMBL6981614 | 0.88 | ADAM17 (0.39) | ADAM17MMP2MMP3MMP7LTA4H | |
| Hydrochloric Acid SCHEMBL6986445 | 0.87 | ADAM17 (0.39) | ADAM17MMP2MMP3MMP7LTA4H | |
| SCHEMBL6943938 | 0.87 | ADAM17 (0.40) | ADAM17MMP2MMP3MMP7LTA4H | |
| Hydrochloric Acid SCHEMBL6978619 | 0.87 | ADAM17 (0.36) | ADAM17MMP2MMP3MMP7LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-A1 | HYDRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000465-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-06 | — | — | WO | disclosed |