P-Xylene

P-Xylene

SCHEMBL7814949

CCO.CO.Cc1ccc(C)cc1

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of P-Xylene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 4/20 0.57
TDP1 Q9NUW8 1/20 0.57
GAA P10253 1/20 0.46
ALDH1A1 P00352 4/20 0.43
CA2 P00918 2/20 0.43
LMNA P02545 1/20 0.43
IDO1 P14902 1/20 0.43
TSHR P16473 1/20 0.43
CES2 O00748 1/20 0.43
CES1 P23141 1/20 0.43
LPL P06858 1/20 0.43
LIPG Q9Y5X9 1/20 0.43
ORAI1 Q96D31 1/20 0.43
ORAI2 Q96SN7 1/20 0.43
ORAI3 Q9BRQ5 1/20 0.43
TRPV6 Q9H1D0 1/20 0.43
CA1 P00915 1/20 0.42
CA7 P43166 1/20 0.42
CA9 Q16790 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
P-Xylene SCHEMBL28248643 0.96 ACHE (0.61) ACHETDP1GAAALDH1A1CA2
P-Xylene SCHEMBL28321095 0.96 ACHE (0.61) ACHETDP1GAAALDH1A1CA2
P-Xylene SCHEMBL4257237 0.96 ACHE (0.61) ACHETDP1GAAALDH1A1CA2
P-Xylene SCHEMBL9720606 0.96 ACHE (0.61) ACHETDP1GAAALDH1A1CA2
P-Xylene SCHEMBL28093113 0.90 ACHE (0.53) ACHETDP1GAAALDH1A1CA2
P-Xylene SCHEMBL28886763 0.87 ACHE (0.50) ACHETDP1GAAALDH1A1LMNA
P-Xylene SCHEMBL4762911 0.86 ACHE (0.57) ACHETDP1GAAALDH1A1CA2
P-Xylene SCHEMBL9720651 0.84 ACHE (0.80) ACHETDP1GAAALDH1A1CA2
P-Xylene SCHEMBL28540852 0.84 ACHE (0.80) ACHETDP1GAAALDH1A1CA2
P-Xylene SCHEMBL6272681 0.84 ACHE (0.80) ACHETDP1GAAALDH1A1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1107972-A1 PREPARATION PROCESS FOR MANUFACTURE AND PURIFICATION OF MIXTURES OF FLUORAN COMPOUNDS AND RECORDING MATERIAL COMPRISING SAID MIXTURES OF FLUORAN Ciba SC Holding AG (CH) 2001-06-20 EP disclosed
WO-2000012513-A1 NOVEL PREPARATION PROCESS FOR MANUFACTURE AND PURIFICATION OF MIXTURES OF FLUORAN COMPOUNDS AND RECORDING MATERIAL COMPRISING SAID MIXTURES OF FLUORAN COMPOUNDS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2000-03-09 WO disclosed