Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 3/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8702882 | 0.81 | MEN1 (0.56) | ALDH1A1LMNA | |
| SCHEMBL7805631 | 0.80 | AKR1C3 (0.45) | AKR1C3AKR1C2ALDH1A1LMNAHTT | |
| SCHEMBL6123335 | 0.78 | ALDH1A1 (0.44) | AKR1C3AKR1C2ALDH1A1LMNAHTT | |
| Hydrochloric Acid SCHEMBL7805469 | 0.78 | AKR1C3 (0.44) | AKR1C3AKR1C2ALDH1A1LMNAHTT | |
| SCHEMBL4025402 | 0.78 | AKR1C3 (0.44) | AKR1C3AKR1C2ALDH1A1LMNAHTT | |
| SCHEMBL6123334 | 0.78 | ALDH1A1 (0.44) | AKR1C3AKR1C2ALDH1A1LMNAHTT | |
| SCHEMBL10653616 | 0.76 | AKR1C3 (0.42) | AKR1C3AKR1C2ALDH1A1LMNAHTT | |
| SCHEMBL10709954 | 0.76 | PPARG (0.47) | AKR1C3AKR1C2KMOPPARGPPARA | |
| SCHEMBL6017403 | 0.76 | AKR1C3 (0.64) | AKR1C3AKR1C2ALDH1A1LMNAHTT | |
| SCHEMBL14192004 | 0.76 | AKR1C3 (0.64) | AKR1C3AKR1C2ALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0823896-B1 | SUBSTITUTED OXIMES, HYDRAZONES AND OLEFINS AS NEUROKININ ANTAGONISTS | SCHERING CORP (US) | 2001-07-11 | — | — | EP | disclosed |
| US-5840725-A | Substituted oximes, hydrazones and olefins as neurokinin antagonists | SCHERING CORPORATION (US) | 1998-11-24 | — | — | US | disclosed |
| EP-0823896-A1 | SUBSTITUTED OXIMES, HYDRAZONES AND OLEFINS AS NEUROKININ ANTAGONISTS | SCHERING CORPORATION (US) | 1998-02-18 | — | — | EP | disclosed |
| US-5696267-A | ANTIHISTAMINES; ANTIINFLAMMATORY AGENTS; GASTROINTESTINAL DISORDERS | SCHERING CORPORATION (US) | 1997-12-09 | — | — | US | disclosed |
| WO-1996034857-A1 | SUBSTITUTED OXIMES, HYDRAZONES AND OLEFINS AS NEUROKININ ANTAGONISTS | SCHERING CORPORATION (US) | 1996-11-07 | — | — | WO | disclosed |