SCHEMBL7815094

SCHEMBL7815094

NCCc1ccc(C=NN)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.50
TAAR1 Q96RJ0 9/20 0.46
HTR2A P28223 3/20 0.46
CYP2A6 P11509 2/20 0.46
CYP1A2 P05177 2/20 0.46
KDM4E B2RXH2 1/20 0.46
ALDH1A1 P00352 1/20 0.46
HTR1A P08908 1/20 0.46
ADRA2A P08913 1/20 0.46
SLC6A2 P23975 1/20 0.46
CYP2C19 P33261 1/20 0.46
HTR3A P46098 1/20 0.46
BACE1 P56817 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
CA1 P00915 2/20 0.45
CA2 P00918 2/20 0.45
CA7 P43166 2/20 0.45
CA9 Q16790 2/20 0.45
CA12 O43570 1/20 0.45
CA4 P22748 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8173515 0.98 MAOB (0.48) MAOBTAAR1HTR2ACYP2A6CYP1A2
SCHEMBL7818544 0.88 MAOB (0.47) MAOBTAAR1HTR2ACYP2A6CA1
Hydrochloric Acid SCHEMBL8173505 0.86 MAOB (0.45) MAOBHTR2ACYP2A6CA1CA2
SCHEMBL6948271 0.82 MAOB (0.54) MAOBTAAR1CA1CA2CA7
SCHEMBL19849879 0.81 MAOB (0.48) MAOBALDH1A1CA1CA2CA7
SCHEMBL8888786 0.81 TAAR1 (0.50) TAAR1HTR2ACYP2A6CYP1A2KDM4E
Hydrochloric Acid SCHEMBL7719897 0.80 MAOB (0.52) MAOBTAAR1CA1CA2CA7
SCHEMBL6779811 0.78 MAOB (0.74) MAOBKDM4EALDH1A1L3MBTL1CA1
SCHEMBL5666445 0.78 MAOB (0.74) MAOBKDM4EALDH1A1L3MBTL1CA1
SCHEMBL11508814 0.78 GRIN2D (0.61) MAOBHTR2AKDM4EALDH1A1ADRA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0925295-B1 N-BENZENESULPHONYL-L-PROLINE DERIVATIVES AS B2 RECEPTOR ANTAGONISTS OF THE BRADYKININ FOURNIER IND & SANTE (FR) 2001-10-04 EP disclosed