Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.50 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7815542 | 1.00 | CYP19A1 (0.51) | CYP19A1MEN1KMT2ATBXAS1EGLN3 | |
| SCHEMBL28054792 | 0.79 | KMT2A (0.53) | CYP19A1MEN1KMT2AALDH1A1HSP90AA1 | |
| SCHEMBL7827152 | 0.78 | TSHR (0.53) | CYP19A1KMT2ATBXAS1ALDH1A1TSHR | |
| SCHEMBL7827149 | 0.78 | TSHR (0.53) | CYP19A1KMT2ATBXAS1ALDH1A1TSHR | |
| SCHEMBL28560792 | 0.77 | CYP19A1 (0.55) | CYP19A1MEN1KMT2AEGLN3ALDH1A1 | |
| SCHEMBL11001574 | 0.75 | KMT2A (0.62) | CYP19A1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL28770476 | 0.75 | CYP19A1 (0.52) | CYP19A1MEN1KMT2AALDH1A1HSP90AA1 | |
| SCHEMBL12158648 | 0.75 | CYP19A1 (0.52) | CYP19A1MEN1KMT2AALDH1A1HSP90AA1 | |
| SCHEMBL28770478 | 0.75 | CYP19A1 (0.52) | CYP19A1MEN1KMT2AALDH1A1HSP90AA1 | |
| SCHEMBL27575719 | 0.73 | KMT2A (0.48) | CYP19A1MEN1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0500864-B1 | ANTIMUSCARINIC BRONCHODILATORS | PFIZER LTD (GB) | 2001-09-19 | — | — | EP | disclosed |
| US-5292749-A | Quinuclidine derivatives; bronchodilator agents, treatment of respiratory system disorders | PFIZER INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0500864-A1 | ANTIMUSCARINIC BRONCHODILATORS | Pfizer Limited (GB) | 1992-09-02 | — | — | EP | disclosed |
| WO-1992004346-A1 | ANTIMUSCARINIC BRONCHODILATORS | PFIZER LIMITED (GB) | 1992-03-19 | — | — | WO | disclosed |