Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 20/20 | 0.67 |
| ▸ | PPARA | Q07869 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7825579 | 0.86 | PPARG (0.81) | PPARGPPARA | |
| SCHEMBL7922700 | 0.80 | PPARG (1.00) | PPARGPPARA | |
| SCHEMBL7920667 | 0.80 | PPARG (0.42) | PPARGPPARA | |
| SCHEMBL7904698 | 0.79 | PPARG (0.66) | PPARGPPARA | |
| SCHEMBL7909717 | 0.79 | PPARG (0.80) | PPARGPPARA | |
| SCHEMBL7824971 | 0.79 | PPARG (0.78) | PPARGPPARA | |
| SCHEMBL9087947 | 0.79 | PPARG (0.89) | PPARGPPARA | |
| SCHEMBL9005926 | 0.79 | PPARG (0.76) | PPARGPPARA | |
| SCHEMBL9005902 | 0.78 | PPARG (0.70) | PPARGPPARA | |
| SCHEMBL9085087 | 0.78 | PPARG (0.81) | PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0648212-B1 | BENZOXAZOLE AND BENZOTHIAZOLE DERIVATIVES AS PHARMACEUTICAL | SMITHKLINE BEECHAM PLC (GB) | 2001-10-24 | — | — | EP | disclosed |
| US-6294580-B1 | FOR THERAPY AND PROPHYLAXIS OF TYPE II OR NON-INSULIN DEPENDENT DIABETES MELLITUS, HYPERGLYCAEMIA, DYSLIPIDEMIA, TYPE II DIABETES, TYPE I DIABETES, HYPERTRIGLYCERIDEMIA, SYNDROME X, INSULIN RESISTANCE, HEART FAILURE | GLAXO WELLCOME INC. | 2001-09-25 | — | — | US | disclosed |
| EP-0888317-B1 | SUBSTITUTED 4-HYDROXY-PHENYLALCANOIC ACID DERIVATIVES WITH AGONIST ACTIVITY TO PPAR-GAMMA | GLAXO GROUP LTD (GB) | 2001-09-12 | — | — | EP | disclosed |
| EP-1000938-A1 | Heterocyclic compounds as pharmaceuticals | SMITHKLINE BEECHAM PLC (GB) | 2000-05-17 | — | — | EP | disclosed |
| US-6048883-A | HYPOGLYCEMIC AGENT | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-04-11 | — | — | US | disclosed |
| EP-0888317-A1 | SUBSTITUTED 4-HYDROXY-PHENYLALCANOIC ACID DERIVATIVES WITH AGONIST ACTIVITY TO PPAR-GAMMA | GLAXO GROUP LIMITED (GB) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997031907-A1 | SUBSTITUTED 4-HYDROXY-PHENYLALCANOIC ACID DERIVATIVES WITH AGONIST ACTIVITY TO PPAR-GAMMA | GLAXO GROUP LIMITED (GB) | 1997-09-04 | — | — | WO | disclosed |
| EP-0648212-A1 | HETEROCYCLIC COMPOUNDS AS PHARMACEUTICAL | SMITHKLINE BEECHAM PLC (GB) | 1995-04-19 | — | — | EP | disclosed |
| WO-1994001420-A1 | HETEROCYCLIC COMPOUNDS AS PHARMACEUTICAL | SMITHKLINE BEECHAM PLC (GB) | 1994-01-20 | — | — | WO | disclosed |