Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | CTSS | P25774 | 7/20 | 0.53 |
| ▸ | CTSL | P07711 | 6/20 | 0.53 |
| ▸ | CTSK | P43235 | 7/20 | 0.52 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.51 |
| ▸ | ELANE | P08246 | 2/20 | 0.51 |
| ▸ | CTSB | P07858 | 4/20 | 0.49 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7609348 | 1.00 | ATM (0.54) | ATMCTSSCTSLCTSKCTRB1 | |
| SCHEMBL7465551 | 1.00 | ATM (0.54) | ATMCTSSCTSLCTSKCTRB1 | |
| SCHEMBL14561268 | 0.87 | ATM (0.56) | ATMCTSSCTSLCTSKCTRB1 | |
| SCHEMBL10387100 | 0.86 | ATM (0.54) | ATMCTSSCTSLCTSKCTRB1 | |
| SCHEMBL6841165 | 0.85 | CTSS (0.61) | ATMCTSSCTSLCTSKCTRB1 | |
| SCHEMBL15691156 | 0.85 | CTSS (0.61) | ATMCTSSCTSLCTSKCTRB1 | |
| SCHEMBL2627372 | 0.84 | ATM (0.58) | ATMCTSSCTSLCTSKCTRB1 | |
| SCHEMBL1823462 | 0.84 | ATM (0.58) | ATMCTSSCTSLCTSKCTRB1 | |
| SCHEMBL15691158 | 0.84 | ATM (0.58) | ATMCTSSCTSLCTSKCTRB1 | |
| SCHEMBL856096 | 0.84 | ATM (0.58) | ATMCTSSCTSLCTSKCTRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1068304-A4 | TREATMENT OF PARASITIC DISEASES BY INHIBITION OF CYSTEINE PROTEASES OF THE PAPAIN SUPERFAMILY | SMITHKLINE BEECHAM CORP (US) | 2001-05-09 | — | — | EP | disclosed |
| EP-1068304-A1 | TREATMENT OF PARASITIC DISEASES BY INHIBITION OF CYSTEINE PROTEASES OF THE PAPAIN SUPERFAMILY | SMITHKLINE BEECHAM CORPORATION (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999053039-A1 | TREATMENT OF PARASITIC DISEASES BY INHIBITION OF CYSTEINE PROTEASES OF THE PAPAIN SUPERFAMILY | SMITHKLINE BEECHAM CORPORATION (US) | 1999-10-21 | — | — | WO | disclosed |