Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 11/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.32 |
| ▸ | PDE4A | P27815 | 4/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.32 |
| ▸ | GAK | O14976 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7816149 | 0.91 | PDE4B (0.34) | PIK3CAPIK3CDPIK3CGPIK3CBPDE4B | |
| SCHEMBL856936 | 0.90 | PIK3CD (0.37) | PIK3CAPIK3CDPIK3CGPIK3CBPDE4B | |
| SCHEMBL7819952 | 0.86 | NPC1 (0.39) | PIK3CAPIK3CDPIK3CGPIK3CBMTOR | |
| SCHEMBL3758729 | 0.84 | PIK3CA (0.33) | PIK3CAPIK3CDPIK3CGPIK3CBPDE4B | |
| SCHEMBL856291 | 0.83 | USP2 (0.34) | PIK3CAPIK3CDPIK3CGPIK3CBGAK | |
| SCHEMBL3763766 | 0.82 | PIK3CA (0.32) | PIK3CAPDE4BPDE4APDE4D | |
| SCHEMBL856623 | 0.82 | PIK3CA (0.36) | PIK3CAPIK3CDPIK3CGPIK3CBMTOR | |
| SCHEMBL3758825 | 0.81 | PDE10A (0.41) | PIK3CAPIK3CDPIK3CGPIK3CBMTOR | |
| SCHEMBL856543 | 0.81 | PIK3CA (0.36) | PIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL15407251 | 0.81 | PIK3CA (0.36) | PIK3CAPIK3CDPIK3CGPIK3CBMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010135568-A1 | BENZOXAZEPINES AS INHIBITORS OF MTOR AND THEIR USE TO TREAT CANCER | EXELIXIS, INC. (US) | 2010-11-25 | — | — | WO | disclosed |