Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.33 |
| ▸ | OGA | O60502 | 2/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7816149 | 0.89 | PDE4B (0.34) | PIK3CAPIK3CGPIK3CDPIK3CB | |
| SCHEMBL858672 | 0.88 | NPC1 (0.36) | NPC1RAB9ASMN1; SMN2PIK3CAPIK3CG | |
| SCHEMBL856936 | 0.87 | PIK3CD (0.37) | RAB9ASMN1; SMN2PIK3CAPIK3CGPIK3CD | |
| SCHEMBL7816145 | 0.86 | PIK3CA (0.34) | PIK3CAPIK3CGPIK3CDPIK3CBMTOR | |
| SCHEMBL858963 | 0.84 | GPR142 (0.36) | NPC1RAB9ASMN1; SMN2PIK3CAPIK3CG | |
| SCHEMBL3758925 | 0.80 | GPR142 (0.36) | PIK3CACREBBP | |
| SCHEMBL856291 | 0.80 | USP2 (0.34) | PIK3CAPIK3CGPIK3CDPIK3CBMTOR | |
| SCHEMBL3758825 | 0.80 | PDE10A (0.41) | PIK3CAPIK3CGPIK3CDPIK3CBMTOR | |
| SCHEMBL3716278 | 0.80 | PIK3CA (0.40) | PIK3CAPIK3CGCREBBP | |
| SCHEMBL858091 | 0.79 | PIK3CA (0.40) | PIK3CAPIK3CGPIK3CDPIK3CBMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010135568-A1 | BENZOXAZEPINES AS INHIBITORS OF MTOR AND THEIR USE TO TREAT CANCER | EXELIXIS, INC. (US) | 2010-11-25 | — | — | WO | disclosed |