Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 9/20 | 0.57 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | SOD1 | P00441 | 1/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13439849 | 0.91 | MAOB (0.61) | MAOBAPPSOD1ABCB1MRGPRX4 | |
| SCHEMBL13439834 | 0.88 | NPC1 (0.58) | MAOBAPPSOD1NR4A1NR4A2 | |
| SCHEMBL791326 | 0.83 | MAOB (0.69) | MAOBAPPNR4A1NR4A2NR4A3 | |
| SCHEMBL78171 | 0.82 | MAOB (0.62) | MAOBSOD1NR4A1NR4A2NR4A3 | |
| SCHEMBL7917111 | 0.82 | MAOB (0.62) | MAOBAPPABCB1MRGPRX4NPC1 | |
| SCHEMBL29303965 | 0.82 | APP (0.58) | MAOBAPPNR4A2LMNAPOLB | |
| SCHEMBL22548672 | 0.79 | MAOB (0.56) | MAOBNR4A2MRGPRX4LMNAHTT | |
| SCHEMBL13761594 | 0.79 | NR4A2 (0.56) | MAOBAPPSOD1NR4A1NR4A2 | |
| SCHEMBL146154 | 0.79 | ACHE (0.52) | SOD1LMNAPOLBHTTL3MBTL1 | |
| SCHEMBL5987976 | 0.79 | MAOB (0.76) | MAOBAPPABCB1MRGPRX4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |