Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 9/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.57 |
| ▸ | KDR | P35968 | 8/20 | 0.57 |
| ▸ | EGFR | P00533 | 7/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7818516 | 0.84 | PDGFRB (0.52) | FGFR1PDGFRBKDREGFRCHEK1 | |
| SCHEMBL8192156 | 0.77 | KDR (0.59) | FGFR1PDGFRBKDREGFRCHEK1 | |
| SCHEMBL6393631 | 0.77 | PDGFRB (0.53) | FGFR1PDGFRBKDREGFRCHEK1 | |
| SCHEMBL6393636 | 0.77 | PDGFRB (0.53) | FGFR1PDGFRBKDREGFRCHEK1 | |
| SCHEMBL14521211 | 0.74 | CHEK1 (0.56) | FGFR1PDGFRBKDREGFRCHEK1 | |
| SCHEMBL4414238 | 0.73 | KDR (0.84) | FGFR1PDGFRBKDREGFRCHEK1 | |
| SCHEMBL4416887 | 0.73 | PDGFRB (0.84) | FGFR1PDGFRBKDREGFRSRC | |
| SCHEMBL4414235 | 0.73 | KDR (0.84) | FGFR1PDGFRBKDREGFRCHEK1 | |
| SCHEMBL4416883 | 0.73 | PDGFRB (0.84) | FGFR1PDGFRBKDREGFRSRC | |
| SCHEMBL6390261 | 0.73 | PDGFRB (1.00) | FGFR1PDGFRBKDREGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066257-A2 | HETEROCYLIC CLASSES OF COMPOUNDS FOR THE MODULATING TYROSINE PROTEIN KINASE | Sugen, Inc. (US) | 2001-01-10 | — | — | EP | disclosed |
| WO-1999048868-A9 | HETEROCYCLIC CLASSES OF COMPOUNDS FOR THE MODULATING TYROSINE PROTEIN KINASE | SUGEN INC (US) | 2000-04-20 | — | — | WO | disclosed |
| WO-1999048868-A2 | HETEROCYCLIC CLASSES OF COMPOUNDS FOR THE MODULATING TYROSINE PROTEIN KINASE | SUGEN, INC. (US) | 1999-09-30 | — | — | WO | disclosed |