Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.59 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.59 |
| ▸ | TLK2 | Q86UE8 | 10/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.55 |
| ▸ | CDK1 | P06493 | 2/20 | 0.53 |
| ▸ | RET | P07949 | 2/20 | 0.53 |
| ▸ | CDK2 | P24941 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | GSK3A | P49840 | 2/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.53 |
| ▸ | CDK7 | P50613 | 2/20 | 0.53 |
| ▸ | CDK9 | P50750 | 2/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8185332 | 0.89 | TLK2 (0.68) | KDRFGFR1PDGFRBTLK2CDK5 | |
| SCHEMBL7828051 | 0.81 | TLK2 (0.72) | KDRFGFR1PDGFRBTLK2CDK5 | |
| SCHEMBL7816356 | 0.77 | FGFR1 (0.57) | KDRFGFR1PDGFRBMAPTCHEK1 | |
| SCHEMBL7832595 | 0.77 | TLK2 (0.67) | KDRFGFR1PDGFRBTLK2CDK5 | |
| SCHEMBL11926760 | 0.77 | TLK2 (0.63) | KDRFGFR1PDGFRBTLK2CDK5 | |
| SCHEMBL6393631 | 0.76 | PDGFRB (0.53) | KDRFGFR1PDGFRBCHEK1CHEK2 | |
| SCHEMBL6393636 | 0.76 | PDGFRB (0.53) | KDRFGFR1PDGFRBCHEK1CHEK2 | |
| SCHEMBL14521185 | 0.75 | CYP19A1 (0.51) | KDRFGFR1PDGFRBTLK2MAPT | |
| SCHEMBL12722125 | 0.75 | TLK2 (0.67) | KDRFGFR1PDGFRBTLK2CDK5 | |
| SCHEMBL6390261 | 0.74 | PDGFRB (1.00) | KDRFGFR1PDGFRBSRCEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999048868-A9 | HETEROCYCLIC CLASSES OF COMPOUNDS FOR THE MODULATING TYROSINE PROTEIN KINASE | SUGEN INC (US) | 2000-04-20 | — | — | WO | disclosed |