Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | WNT3A | P56704 | 7/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6670617 | 0.89 | CTSL (0.46) | CTSLCTSBCTSSPRMT5WDR77 | |
| SCHEMBL6670621 | 0.89 | CTSL (0.46) | CTSLCTSBCTSSPRMT5WDR77 | |
| SCHEMBL7616026 | 0.89 | CTSL (0.46) | CTSLCTSBCTSSPRMT5WDR77 | |
| SCHEMBL6926995 | 0.84 | PRMT5 (0.49) | CTSLCTSBCTSSPRMT5WDR77 | |
| SCHEMBL6623377 | 0.83 | CTSL (0.47) | CTSLCTSBCTSSPRMT5WDR77 | |
| SCHEMBL7611319 | 0.81 | CTSL (0.45) | CTSLCTSBCTSSPRMT5WDR77 | |
| SCHEMBL7816127 | 0.80 | CTSL (0.44) | CTSLCTSBCTSSCTSKFFAR1 | |
| SCHEMBL10242894 | 0.79 | CYP4F2 (0.50) | CTSLCTSBCTSSCTSKFFAR1 | |
| SCHEMBL7618089 | 0.79 | CTSL (0.45) | CTSLCTSBCTSSPRMT5WDR77 | |
| SCHEMBL7408937 | 0.79 | FFAR1 (0.49) | CTSLCTSBCTSSFFAR1WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1068304-A4 | TREATMENT OF PARASITIC DISEASES BY INHIBITION OF CYSTEINE PROTEASES OF THE PAPAIN SUPERFAMILY | SMITHKLINE BEECHAM CORP (US) | 2001-05-09 | — | — | EP | disclosed |
| EP-1068304-A1 | TREATMENT OF PARASITIC DISEASES BY INHIBITION OF CYSTEINE PROTEASES OF THE PAPAIN SUPERFAMILY | SMITHKLINE BEECHAM CORPORATION (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999053039-A1 | TREATMENT OF PARASITIC DISEASES BY INHIBITION OF CYSTEINE PROTEASES OF THE PAPAIN SUPERFAMILY | SMITHKLINE BEECHAM CORPORATION (US) | 1999-10-21 | — | — | WO | disclosed |