Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 11/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | PRNP | P04156 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL856354 | 0.94 | PIK3CA (0.47) | PIK3CALMNAHTTMAPTNPSR1 | |
| SCHEMBL861229 | 0.90 | PIK3CA (0.47) | PIK3CALMNAHTTMAPTNPSR1 | |
| SCHEMBL3764793 | 0.89 | PIK3CA (0.49) | PIK3CALMNAHTTMAPTNPSR1 | |
| SCHEMBL7823835 | 0.87 | PIK3CA (0.48) | PIK3CALMNAHTTMAPTNPSR1 | |
| SCHEMBL861601 | 0.87 | PIK3CA (0.48) | PIK3CALMNAHTTMAPTNPSR1 | |
| SCHEMBL7860271 | 0.86 | PIK3CA (0.47) | PIK3CALMNAHTTMAPTNPSR1 | |
| SCHEMBL857836 | 0.86 | PIK3CA (0.45) | PIK3CALMNAHTTMAPTNPSR1 | |
| SCHEMBL855583 | 0.86 | PIK3CA (0.49) | PIK3CALMNAHTTMAPTNPSR1 | |
| SCHEMBL856295 | 0.85 | PIK3CA (0.47) | PIK3CALMNAHTTMAPTNPSR1 | |
| SCHEMBL857187 | 0.85 | PIK3CA (0.51) | PIK3CALMNAHTTMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010135568-A1 | BENZOXAZEPINES AS INHIBITORS OF MTOR AND THEIR USE TO TREAT CANCER | EXELIXIS, INC. (US) | 2010-11-25 | — | — | WO | disclosed |