Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 2/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15177374 | 0.95 | BLM (0.40) | BLMPMP22HSD17B10CYP2D6CHRM2 | |
| SCHEMBL21711103 | 0.90 | CYP2D6 (0.37) | BLMPMP22HSD17B10CYP2D6CHRM2 | |
| SCHEMBL18412664 | 0.90 | BLM (0.36) | BLMPMP22HSD17B10TDP1 | |
| SCHEMBL12735158 | 0.84 | TRPA1 (0.39) | BLMPMP22HSD17B10CYP2D6CHRM2 | |
| SCHEMBL8830981 | 0.83 | MAPK1 (0.38) | BLMPMP22HSD17B10CYP2D6CHRM2 | |
| SCHEMBL6827871 | 0.80 | PIK3CD (0.43) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL19546089 | 0.80 | BLM (0.41) | BLMPMP22HSD17B10CYP2D6CHRM2 | |
| SCHEMBL6347011 | 0.79 | BLM (0.58) | BLMPMP22HSD17B10CYP2D6CHRM2 | |
| SCHEMBL3571283 | 0.77 | TSHR (0.40) | BLMPMP22HSD17B10CYP2D6CHRM2 | |
| SCHEMBL7816887 | 0.77 | BLM (0.40) | BLMPMP22HSD17B10CYP2D6CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757682-B1 | BENZOFURAN DERIVATIVES USEFUL AS INHIBITORS OF BONE RESORPTION | FUJISAWA PHARMACEUTICAL CO (JP) | 2001-06-20 | — | — | EP | disclosed |
| US-5858995-A | ADMINISTERING TO HUMANS AND ANIMALS IN THE TREATMENT OF DISEASES CAUSED BY ABNORMAL BONE METABOLISM | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-01-12 | — | — | US | disclosed |