Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 9/20 | 0.43 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10601800 | 0.98 | HTR2C (0.45) | HTR2CSLC18A3SIGMAR1HTR2AHTR1A | |
| Phosphoric Acid SCHEMBL10597412 | 0.90 | CYP2D6 (0.38) | HTR2CSLC18A3SIGMAR1HTR2AHTR1A | |
| SCHEMBL10600660 | 0.86 | SLC6A2 (0.42) | HTR2CHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10903463 | 0.86 | SLC6A2 (0.39) | HTR2CHTR2AHTR1ASLC6A2SLC6A4 | |
| SCHEMBL10905563 | 0.86 | HTR2C (0.35) | HTR2CHTR2AHTR1ASLC6A2SLC6A4 | |
| SCHEMBL10598002 | 0.86 | HTR1A (0.42) | HTR2CHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10600391 | 0.86 | HTR2C (0.35) | HTR2CSLC18A3SIGMAR1HTR2AHTR1A | |
| SCHEMBL10600422 | 0.86 | HTR2C (0.41) | HTR2CHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10597137 | 0.86 | HTR2C (0.35) | HTR2CSLC18A3SIGMAR1HTR2AHTR1A | |
| Hydrochloric Acid SCHEMBL10970209 | 0.85 | SLC6A2 (0.39) | HTR2CHTR1ASLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733043-B1 | TRICYCLIC DERIVATIVES AND THEIR USE IN PHARMACEUTICALS | SCHERING CORP (US) | 2001-06-20 | — | — | EP | disclosed |
| EP-0157399-B1 | 4-(5H-Dibenzo[a,d]cyclohepten-5-yl) piperidine compounds | MERCK & CO. INC. (US) | 1989-08-16 | — | — | EP | disclosed |
| EP-0157399-B1 | 4-(5H-Dibenzo[a,d]cyclohepten-5-yl) piperidine compounds | MERCK & CO. INC. (US) | 1989-08-16 | — | — | EP | disclosed |
| US-4758577-A | 4-(5H-dibenzo[a,d]cyclohepten-5-yl)piperidine compounds for treating cardiovascular disorders | MERCK & CO., INC. (US) | 1988-07-19 | — | — | US | disclosed |
| US-4758577-A | 4-(5H-dibenzo[a,d]cyclohepten-5-yl)piperidine compounds for treating cardiovascular disorders | MERCK & CO., INC. (US) | 1988-07-19 | — | — | US | disclosed |
| US-4758577-A | 4-(5H-dibenzo[a,d]cyclohepten-5-yl)piperidine compounds for treating cardiovascular disorders | MERCK & CO., INC. (US) | 1988-07-19 | — | — | US | disclosed |
| US-4626542-A | CARDIOVASCULAR DISORDERS | MERCK & CO., INC. (US) | 1986-12-02 | — | — | US | disclosed |
| US-4626542-A | CARDIOVASCULAR DISORDERS | MERCK & CO., INC. (US) | 1986-12-02 | — | — | US | disclosed |
| US-4626542-A | CARDIOVASCULAR DISORDERS | MERCK & CO., INC. (US) | 1986-12-02 | — | — | US | disclosed |
| EP-0157399-A2 | 4-(5H-Dibenzo[a,d]cyclohepten-5-yl) piperidine compounds | MERCK & CO. INC. (US) | 1985-10-09 | — | — | EP | disclosed |
| EP-0157399-A2 | 4-(5H-Dibenzo[a,d]cyclohepten-5-yl) piperidine compounds | MERCK & CO. INC. (US) | 1985-10-09 | — | — | EP | disclosed |
| EP-0157399-A2 | 4-(5H-Dibenzo[a,d]cyclohepten-5-yl) piperidine compounds | MERCK & CO. INC. (US) | 1985-10-09 | — | — | EP | disclosed |