Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
| ▸ | PTGIR | P43119 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7817626 | 0.84 | NISCH (0.48) | NISCHALDH1A1SMN1; SMN2TSHRNPSR1 | |
| SCHEMBL6098334 | 0.84 | NISCH (0.48) | NISCHALDH1A1SMN1; SMN2TSHRNPSR1 | |
| SCHEMBL14367857 | 0.82 | NISCH (0.46) | NISCHALDH1A1SMN1; SMN2TSHRNPSR1 | |
| SCHEMBL14367874 | 0.82 | NISCH (0.46) | NISCHALDH1A1SMN1; SMN2TSHRNPSR1 | |
| SCHEMBL7820154 | 0.81 | NISCH (0.45) | NISCHALDH1A1SMN1; SMN2TSHRNPSR1 | |
| SCHEMBL7820300 | 0.80 | TP53 (0.49) | NISCHALDH1A1SMN1; SMN2TSHRTP53 | |
| SCHEMBL8182555 | 0.76 | ALDH1A1 (0.48) | NISCHALDH1A1SMN1; SMN2TP53MEN1 | |
| SCHEMBL5645322 | 0.74 | NISCH (0.50) | NISCHALDH1A1SMN1; SMN2TP53MEN1 | |
| SCHEMBL7820989 | 0.74 | NISCH (0.62) | NISCH | |
| SCHEMBL15724686 | 0.72 | HRH3 (0.41) | TSHRNPSR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0894796-B1 | Imidazolines substituted with a heterocyclic ring as alpha-2 antagonists | ADIR (FR) | 2001-06-06 | — | — | EP | disclosed |
| US-6057317-A | Heterocyclic compounds | ADIR ET COMPAGNIE (FR) | 2000-05-02 | — | — | US | disclosed |
| EP-0894796-A1 | Imidazolines substituted with a heterocyclic ring as alpha-2 antagonists | ADIR ET COMPAGNIE (FR) | 1999-02-03 | — | — | EP | disclosed |