Acetic Acid — predicted protein targets

Known targets — ChEMBL curated mechanism

ADRA2A ADRA2B ADRA2C ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CALCR CHRNA3 CHRNB4 ESR1 ESR2 GHSR GNRHR GSC1 HSPA8 MALT1 MC1R MC4R NOS1 NOS2 NOS3 OPRK1 OXTR RAMP1 RAMP2 RAMP3 SCN5A SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 dacA dacB dacC folP ftsI mrcA mrcB mrdA rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 15)

	gene	UniProt	supporting neighbours	confidence
▸	CFTR	P13569	1/20	0.35

▸	MAPK1	P28482	2/20	0.34

▸	MEN1	O00255	1/20	0.34

▸	KMT2A	Q03164	1/20	0.34

▸	TDP1	Q9NUW8	8/20	0.33

▸	MAPT	P10636	3/20	0.33

▸	GSK3B	P49841	1/20	0.33

▸	QPCT	Q16769	1/20	0.33

▸	ASH1L	Q9NR48	1/20	0.33

▸	GAA	P10253	1/20	0.33

▸	TP53	P04637	1/20	0.33

▸	ALDH1A1	P00352	2/20	0.33

▸	L3MBTL1	Q9Y468	1/20	0.33

▸	POLB	P06746	1/20	0.33

▸	HTT	P42858	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Acetic Acid SCHEMBL7820633	0.92	CFTR (0.37)	CFTRMAPK1MEN1KMT2ATDP1
Acetic Acid SCHEMBL7815335	0.92	TDP1 (0.41)	CFTRTDP1MAPT
Acetic Acid SCHEMBL7817642	0.84	CFTR (0.41)	CFTRTDP1
Acetic Acid SCHEMBL7807266	0.83	TP53 (0.39)	CFTRMAPK1MEN1KMT2AMAPT
Acetic Acid SCHEMBL7817026	0.82	CFTR (0.39)	CFTRMAPK1MEN1KMT2ATDP1
Acetic Acid SCHEMBL7814541	0.81	TP53 (0.38)	MAPK1MEN1KMT2ATP53ALDH1A1
Acetic Acid SCHEMBL7820632	0.79	MAPT (0.39)	MEN1KMT2AMAPTGSK3BQPCT
Acetic Acid SCHEMBL7817871	0.78	ALDH1A1 (0.42)	CFTRMAPK1MEN1KMT2AMAPT
Acetic Acid SCHEMBL7815363	0.77	CFTR (0.45)	CFTRMEN1KMT2ATDP1MAPT
Acetic Acid SCHEMBL7821126	0.76	ASH1L (0.40)	CFTRMAPK1TDP1MAPTGSK3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20010025043-A1	New pharmaceutical active compounds	ASTRA AKTIEBOLAG, A SWEDEN CORPORATION	2001-09-27	—	—	US	disclosed
US-6271231-B1	Pharmaceutically active compounds	ASTRA AKTIEBOLAG (SE)	2001-08-07	—	—	US	disclosed
EP-0929551-A1	NEW PHARMACEUTICALLY ACTIVE COMPOUNDS	Astra Aktiebolag (publ) (SE)	1999-07-21	—	—	EP	disclosed
WO-1998013368-A1	NEW PHARMACEUTICALLY ACTIVE COMPOUNDS	ASTRA AKTIEBOLAG (PUBL) (SE)	1998-04-02	—	—	WO	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20010025043-A1	New pharmaceutical active compounds	CSNK1A1, CSNK1G1, CSNK2A1	CFTR 877/4885MAPK1 48/4885MEN1 964/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.