Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 19/20 | 0.61 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.61 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7825524 | 0.87 | F2 (0.60) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7819433 | 0.86 | F2 (0.62) | F2PRSS1PRSS2PRSS3PIK3CD | |
| SCHEMBL7811676 | 0.86 | F2 (0.52) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7809378 | 0.85 | F2 (0.44) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7820059 | 0.85 | F2 (0.51) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7819935 | 0.85 | F2 (0.46) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7818207 | 0.84 | F2 (0.47) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7822527 | 0.84 | MEN1 (0.46) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7817991 | 0.84 | F2 (0.52) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7847492 | 0.84 | F2 (0.45) | F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900207-B1 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |
| US-6093717-A | A SERINE PROTEASE INHIBITOR PREVENTING CORONARY ARTERY DISEASE AND INHIBITING THROMBUS FORMATION IN BLOOD | MERCK & CO., INC. (US) | 2000-07-25 | — | — | US | disclosed |