Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 15/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 8/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.45 |
| ▸ | MASP2 | O00187 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7817861 | 0.84 | F2 (0.61) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7811676 | 0.83 | F2 (0.52) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL7825524 | 0.82 | F2 (0.60) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL7820059 | 0.82 | F2 (0.51) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL7819433 | 0.82 | F2 (0.62) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL7819935 | 0.82 | F2 (0.46) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL7818207 | 0.82 | F2 (0.47) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL7825334 | 0.80 | F2 (0.50) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL7817160 | 0.79 | F2 (0.41) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL8420322 | 0.79 | F2 (0.61) | F2PRSS1PRSS2PRSS3MASP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900207-B1 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |
| US-5866573-A | Pyrazinone thrombin inhibitors | MERCK & CO., INC. (US) | 1999-02-02 | — | — | US | disclosed |