Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.87 |
| ▸ | CASP3 | P42574 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | PTPRC | P08575 | 1/20 | 0.57 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.57 |
| ▸ | CCNE2 | O96020 | 5/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.56 |
| ▸ | CDK2 | P24941 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | CDK4 | P11802 | 1/20 | 0.54 |
| ▸ | CCND1 | P24385 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2601918 | 0.93 | MAOA (1.00) | MAOACASP3ALDH1A1KDM4EGAA | |
| SCHEMBL20334273 | 0.91 | MAOA (0.90) | MAOACASP3ALDH1A1KDM4EGAA | |
| SCHEMBL6370986 | 0.87 | MAOA (0.77) | MAOACASP3ALDH1A1KDM4EGAA | |
| SCHEMBL13564105 | 0.86 | MAOA (0.71) | MAOACASP3ALDH1A1KDM4EGAA | |
| SCHEMBL5051010 | 0.86 | MAOA (0.87) | MAOACASP3ALDH1A1KDM4EGAA | |
| SCHEMBL29986841 | 0.86 | MAOA (0.87) | MAOACASP3ALDH1A1KDM4EGAA | |
| SCHEMBL11656337 | 0.85 | MAOA (0.64) | MAOACASP3ALDH1A1KDM4EGAA | |
| SCHEMBL20892849 | 0.83 | MAOA (0.62) | MAOAALDH1A1KDM4EGAAPTPRC | |
| SCHEMBL20978637 | 0.82 | MAOA (0.79) | MAOACASP3ALDH1A1KDM4EGAA | |
| SCHEMBL9846483 | 0.82 | MAOA (0.74) | MAOACASP3ALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10308607-B2 | Fucosidase inhibitors | HORIZON ORPHAN LLC (US) | 2019-06-04 | — | — | US | disclosed |
| US-9951013-B2 | Fucosidase inhibitors | HORIZON ORPHAN LLC (US) | 2018-04-24 | — | — | US | disclosed |
| US-20170029376-A1 | FUCOSIDASE INHIBITORS | RAPTOR PHARMACEUTICALS INC. (US) | 2017-02-02 | — | — | US | disclosed |
| EP-1066257-A2 | HETEROCYLIC CLASSES OF COMPOUNDS FOR THE MODULATING TYROSINE PROTEIN KINASE | Sugen, Inc. (US) | 2001-01-10 | — | — | EP | disclosed |
| WO-1999048868-A9 | HETEROCYCLIC CLASSES OF COMPOUNDS FOR THE MODULATING TYROSINE PROTEIN KINASE | SUGEN INC (US) | 2000-04-20 | — | — | WO | disclosed |
| WO-1999048868-A2 | HETEROCYCLIC CLASSES OF COMPOUNDS FOR THE MODULATING TYROSINE PROTEIN KINASE | SUGEN, INC. (US) | 1999-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170029376-A1 | FUCOSIDASE INHIBITORS | FUCA1, FUCA2, ENGASE | MAOA 962/4885CASP3 3176/4885ALDH1A1 588/4885 |
| US-10308607-B2 | Fucosidase inhibitors | FUCA1, FUCA2, ENGASE | MAOA 962/4885CASP3 3176/4885ALDH1A1 588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.