SCHEMBL7819355

SCHEMBL7819355

Cc1cccc(NC(=O)N[C@@H]2N=C(NCCN(C)C)c3ccccc3N(C)C2=O)c1

nearest known ligand 0.65

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CCKBR P32239 20/20 0.65
KCNH2 Q12809 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7824167 0.99 CCKBR (0.64) CCKBRKCNH2
SCHEMBL7816322 0.80 CCKBR (0.75) CCKBRKCNH2
SCHEMBL7816551 0.80 CCKBR (0.69) CCKBRKCNH2
SCHEMBL7820320 0.79 CCKBR (0.58) CCKBRKCNH2
L-365260 SCHEMBL9843248 0.79 CCKBR (1.00) CCKBRKCNH2
L-365260 SCHEMBL29694194 0.79 CCKBR (1.00) CCKBRKCNH2
L-365260 SCHEMBL29403509 0.79 CCKBR (1.00) CCKBRKCNH2
L-365260 SCHEMBL31616010 0.79 CCKBR (1.00) CCKBRKCNH2
L-365260 SCHEMBL31616154 0.79 CCKBR (1.00) CCKBRKCNH2
L-365260 SCHEMBL5931098 0.79 CCKBR (1.00) CCKBRKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0652871-B1 BENZODIAZEPINE DERIVATIVES MERCK SHARP & DOHME (GB) 2001-10-17 EP claimed
EP-0652871-A1 BENZODIAZEPINE DERIVATIVES MERCK SHARP & DOHME LTD. (GB) 1995-05-17 EP claimed
WO-1994003437-A1 BENZODIAZEPINE DERIVATIVES MERCK SHARP & DOHME LIMITED (GB) 1994-02-17 WO claimed