Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6422897 | 0.87 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1TSHRKDM4ELMNA | |
| SCHEMBL9124782 | 0.82 | TSHR (0.39) | SMN1; SMN2ALDH1A1TSHRKDM4EKMT2A | |
| SCHEMBL10694004 | 0.77 | SMN1; SMN2 (0.37) | SMN1; SMN2ALDH1A1TSHRKDM4EKMT2A | |
| SCHEMBL1045991 | 0.73 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1TSHRKDM4ELMNA | |
| SCHEMBL15678571 | 0.70 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1TSHRKDM4EKMT2A | |
| SCHEMBL1666966 | 0.69 | ALDH1A1 (0.50) | ALDH1A1TSHRKDM4ELMNAKMT2A | |
| SCHEMBL13261284 | 0.68 | HTT (0.41) | SMN1; SMN2TSHRKDM4EKMT2AMEN1 | |
| SCHEMBL2053373 | 0.68 | KDM4E (0.45) | SMN1; SMN2ALDH1A1TSHRKDM4EKMT2A | |
| SCHEMBL27265888 | 0.67 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1TSHRKDM4ELMNA | |
| SCHEMBL2693461 | 0.67 | TSHR (0.41) | ALDH1A1TSHRKDM4ELMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102754-A1 | IMIDAZOLES AND RELATED COMPOUNDS AS ALPHA-1A AGONISTS | ABBOTT LABORATORIES (US) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007997-A1 | IMIDAZOLES AND RELATED COMPOUNDS AS α1A AGONISTS | ABBOTT LABORATORIES (US) | 2000-02-17 | — | — | WO | disclosed |