Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.43 |
| ▸ | PAX2 | Q02962 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GALR3 | O60755 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5674713 | 0.85 | ALDH1A1 (0.47) | TSHRALDH1A1KDM4EENPP1HSD17B10 | |
| SCHEMBL8686955 | 0.85 | ALDH1A1 (0.47) | TSHRALDH1A1KDM4EENPP1HSD17B10 | |
| SCHEMBL20482747 | 0.81 | ALDH1A1 (0.46) | TSHRALDH1A1KDM4EENPP1HSD17B10 | |
| SCHEMBL7117782 | 0.81 | ALDH1A1 (0.44) | TSHRALDH1A1KDM4EENPP1HSD17B10 | |
| SCHEMBL353089 | 0.80 | HSD17B10 (0.55) | TSHRALDH1A1KDM4EENPP1PAX2 | |
| SCHEMBL5463475 | 0.79 | ALDH1A1 (0.51) | ALDH1A1KDM4EENPP1USP2HTT | |
| SCHEMBL1646899 | 0.78 | ALDH1A1 (0.50) | TSHRALDH1A1ENPP1HSD17B10KMT2A | |
| SCHEMBL10407277 | 0.77 | TSHR (0.50) | TSHRALDH1A1KDM4EENPP1PAX2 | |
| SCHEMBL10407276 | 0.77 | TSHR (0.50) | TSHRALDH1A1ENPP1PAX2HSD17B10 | |
| SCHEMBL22968432 | 0.77 | TSHR (0.50) | TSHRALDH1A1ENPP1PAX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10357481-B2 | Substituted triazolo bicyclic compounds as PDE2 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2019-07-23 | — | — | US | disclosed |
| US-20180169072-A1 | SUBSTITUTED TRIAZOLO BICYCLIC COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME LLC | 2018-06-21 | — | — | US | disclosed |
| EP-1149835-A1 | FAT ACCUMULATION INHIBITORY AGENTS | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 2001-10-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180169072-A1 | SUBSTITUTED TRIAZOLO BICYCLIC COMPOUNDS AS PDE2 INHIBITORS | PDE2A, PDE3A, PDE4D | TSHR 1566/4885ALDH1A1 1376/4885KDM4E 2962/4885 |
| US-10357481-B2 | Substituted triazolo bicyclic compounds as PDE2 inhibitors | PDE2A, PDE3A, PDE4D | TSHR 1566/4885ALDH1A1 1376/4885KDM4E 2962/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.