Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 14/20 | 0.53 |
| ▸ | TDO2 | P48775 | 2/20 | 0.38 |
| ▸ | PDE8B | O95263 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3476353 | 0.91 | GRM2 (0.45) | GRM2CRHR1CRHR2 | |
| SCHEMBL3476571 | 0.86 | GRM2 (0.53) | GRM2TDO2PDE8BCRHR1CRHR2 | |
| SCHEMBL3469755 | 0.80 | CNR1 (0.37) | GRM2 | |
| SCHEMBL3475550 | 0.78 | GRM2 (0.50) | GRM2TDO2 | |
| SCHEMBL3476225 | 0.78 | GRM2 (0.47) | GRM2TDO2 | |
| SCHEMBL3473832 | 0.78 | GRM2 (0.55) | GRM2TDO2 | |
| SCHEMBL8514197 | 0.77 | GRM2 (0.48) | GRM2 | |
| SCHEMBL8513038 | 0.77 | GRM2 (0.46) | GRM2 | |
| SCHEMBL8511014 | 0.76 | GRM2 (0.61) | GRM2TDO2 | |
| SCHEMBL3475311 | 0.76 | GRM2 (0.52) | GRM2TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010141360-A1 | BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2010-12-09 | — | — | WO | disclosed |