Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 14/20 | 0.45 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7819934 | 0.91 | GRM2 (0.53) | GRM2CRHR1CRHR2 | |
| SCHEMBL3476571 | 0.78 | GRM2 (0.53) | GRM2CRHR1CRHR2 | |
| SCHEMBL3476360 | 0.77 | GRM2 (0.41) | GRM2DHFR | |
| SCHEMBL3469755 | 0.75 | CNR1 (0.37) | GRM2 | |
| SCHEMBL3476057 | 0.71 | GRM2 (0.46) | GRM2 | |
| SCHEMBL7882853 | 0.70 | GRM2 (0.40) | GRM2 | |
| SCHEMBL8511570 | 0.69 | GRM2 (0.61) | GRM2 | |
| SCHEMBL3475311 | 0.69 | GRM2 (0.52) | GRM2L3MBTL1 | |
| SCHEMBL3478646 | 0.68 | GRM2 (0.51) | GRM2 | |
| SCHEMBL8509653 | 0.68 | GRM2 (0.46) | GRM2DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010141360-A1 | BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2010-12-09 | — | — | WO | claimed |
| WO-2010141360-A1 | BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2010-12-09 | — | — | WO | disclosed |