Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL69696 | 0.87 | MEN1 (0.44) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL20455602 | 0.86 | MEN1 (0.42) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL15273734 | 0.84 | MEN1 (0.43) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL1267001 | 0.84 | KDM4E (0.45) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL29092152 | 0.83 | PLA2G10 (0.49) | PLA2G10MEN1KMT2ALMNAGSK3B | |
| SCHEMBL3055353 | 0.83 | MEN1 (0.45) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL18904958 | 0.79 | BAZ2B (0.53) | PLA2G10MEN1KMT2AMAPTLMNA | |
| SCHEMBL286598 | 0.79 | CA12 (0.42) | MAPTALDH1A1HPGDNPC1SMN1; SMN2 | |
| SCHEMBL14351941 | 0.77 | PLA2G10 (0.44) | PLA2G10MEN1KMT2AMAPTLMNA | |
| Hydrochloric Acid SCHEMBL286597 | 0.77 | CA12 (0.41) | MAPTALDH1A1HPGDNPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123296-A1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | Pfizer Limited (GB) | 2001-08-16 | — | — | EP | disclosed |
| WO-2000024745-A1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER LIMITED (GB) | 2000-05-04 | — | — | WO | disclosed |